| SP | Pettitte, A.Pettitte, Andy # >> | 25 | 1997 | L | 82 | 18 | 18 | 4 | 9 | 4.59 | .326 | 1.43 | 9.9 | 3.1 | 5.7 | 113.2 | 124 | 61 | 58 | 7 | 39 | 71 | 0 | 0 | 0 | 0 | 9 | 2 | 4 | 3.64 |
| SP | Salazar, D.Salazar, Danny >> | 26 | 2016 | R | 71 | 18 | 18 | 5 | 9 | 4.58 | .355 | 1.63 | 8.7 | 6.0 | 8.5 | 90.1 | 87 | 57 | 46 | 10 | 60 | 85 | 0 | 0 | 0 | 0 | 5 | 2 | 5 | 4.62 |
| SP | Harden, R.Harden, Rich >> | 28 | 2009 | R | 74 | 19 | 18 | 3 | 10 | 4.88 | .349 | 1.56 | 9.3 | 4.8 | 7.7 | 94.0 | 97 | 61 | 51 | 9 | 50 | 80 | 0 | 0 | 0 | 0 | 3 | 4 | 2 | 4.27 |
| SP | Maddux, G.Maddux, Greg >> | 39 | 2005 | R | 65 | 17 | 17 | 5 | 8 | 5.38 | .362 | 1.64 | 12.1 | 2.7 | 4.1 | 95.1 | 128 | 73 | 57 | 9 | 28 | 43 | 0 | 0 | 0 | 0 | 6 | 6 | 2 | 4.40 |
| CL | Feliz, N.Feliz, Neftali >> | 22 | 2010 | R | 99 | 35 | 0 | 2 | 5 | 4.58 | .354 | 1.64 | 9.8 | 5.1 | 8.2 | 35.1 | 38 | 25 | 18 | 4 | 20 | 32 | 0 | 8 | 4 | 0 | 0 | 0 | 2 | 4.37 |
| SU | Chavez, J.Chavez, Jesse >> | 35 | 2018 | R | 77 | 45 | 0 | 0 | 1 | 2.24 | .270 | 1.08 | 6.6 | 3.2 | 6.2 | 68.1 | 50 | 25 | 17 | 4 | 24 | 47 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.53 |
| RP | Brantley, J.Brantley, Jeff >> | 35 | 1998 | R | 76 | 45 | 0 | 3 | 1 | 2.15 | .284 | 1.17 | 7.0 | 3.6 | 6.3 | 50.1 | 39 | 15 | 12 | 4 | 20 | 35 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.90 |
| RP | Kennedy, I.Kennedy, Ian >> | 35 | 2019 | R | 46 | 15 | 0 | 2 | 1 | 4.15 | .381 | 1.79 | 11.1 | 5.3 | 4.8 | 17.1 | 21 | 11 | 8 | 1 | 10 | 9 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.65 |
| RP | Bradford, C.Bradford, Chad >> | 28 | 2002 | R | 60 | 20 | 0 | 1 | 1 | 4.50 | .341 | 1.56 | 12.0 | 2.0 | 6.5 | 18.0 | 24 | 9 | 9 | 2 | 4 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Johnson, P.Johnson, Pierce >> | 32 | 2023 | R | 31 | 8 | 0 | 0 | 0 | 1.00 | .229 | 0.89 | 6.0 | 2.0 | 6.0 | 9.0 | 6 | 3 | 1 | 0 | 2 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.33 |