| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 30 | 30 | 15 | 11 | 4.04 | .287 | 1.18 | 8.1 | 2.5 | 10.2 | 200.2 | 181 | 91 | 90 | 22 | 56 | 227 | 6 | 0 | 0 | 2 | 18 | 5 | 0 | 3.08 |
| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 29 | 29 | 15 | 7 | 3.96 | .290 | 1.21 | 8.3 | 2.6 | 8.3 | 206.2 | 191 | 92 | 91 | 25 | 60 | 191 | 5 | 0 | 0 | 2 | 15 | 2 | 9 | 3.63 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 77 | 29 | 29 | 7 | 14 | 5.94 | .340 | 1.53 | 10.3 | 3.5 | 8.9 | 175.2 | 200 | 119 | 116 | 33 | 68 | 173 | 1 | 0 | 0 | 0 | 10 | 3 | 4 | 4.69 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 29 | 29 | 6 | 10 | 5.33 | .355 | 1.64 | 10.3 | 4.5 | 7.5 | 123.1 | 141 | 73 | 73 | 22 | 61 | 103 | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 5.19 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 58 | 28 | 28 | 8 | 11 | 4.97 | .334 | 1.48 | 8.7 | 4.6 | 6.0 | 175.2 | 170 | 99 | 97 | 28 | 90 | 117 | 3 | 0 | 0 | 0 | 13 | 4 | 3 | 5.35 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 79 | 0 | 11 | 2 | 2.34 | .269 | 1.07 | 5.5 | 4.1 | 10.5 | 111.2 | 68 | 29 | 29 | 6 | 51 | 130 | 0 | 6 | 3 | 0 | 0 | 4 | 5 | 2.85 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 60 | 0 | 5 | 2 | 3.31 | .251 | 1.01 | 7.1 | 2.0 | 11.0 | 84.1 | 66 | 34 | 31 | 17 | 19 | 103 | 0 | 7 | 0 | 0 | 0 | 0 | 3 | 3.86 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 74 | 59 | 0 | 6 | 3 | 3.43 | .301 | 1.23 | 7.3 | 3.9 | 8.6 | 65.2 | 53 | 26 | 25 | 9 | 28 | 62 | 0 | 5 | 2 | 0 | 0 | 4 | 1 | 4.37 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 46 | 0 | 3 | 3 | 3.12 | .313 | 1.35 | 7.1 | 5.0 | 11.1 | 52.0 | 41 | 18 | 18 | 4 | 29 | 64 | 0 | 6 | 3 | 0 | 0 | 1 | 1 | 3.27 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 37 | 0 | 1 | 0 | 1.81 | .256 | 1.03 | 6.3 | 3.1 | 10.8 | 44.2 | 31 | 12 | 9 | 3 | 15 | 53 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 2.50 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 10 | 0 | 2 | 0 | 4.97 | .377 | 1.74 | 10.5 | 6.0 | 6.0 | 12.2 | 14 | 7 | 7 | 1 | 8 | 8 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.00 |