| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 36 | 36 | 12 | 14 | 4.12 | .309 | 1.31 | 9.1 | 2.7 | 6.1 | 251.0 | 253 | 122 | 115 | 28 | 76 | 169 | 2 | 0 | 0 | 0 | 20 | 7 | 4 | 4.10 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 35 | 35 | 15 | 15 | 3.80 | .285 | 1.18 | 8.6 | 2.0 | 4.8 | 260.1 | 247 | 120 | 110 | 25 | 59 | 139 | 11 | 0 | 0 | 2 | 20 | 6 | 3 | 3.93 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 34 | 33 | 10 | 13 | 4.22 | .317 | 1.38 | 7.1 | 5.4 | 7.5 | 215.1 | 169 | 103 | 101 | 19 | 129 | 178 | 1 | 0 | 0 | 0 | 20 | 2 | 1 | 4.32 |
| SP | Carlton, S.Carlton, Steve # >> | 28 | 1972 | L | 51 | 31 | 31 | 13 | 13 | 4.84 | .315 | 1.36 | 9.1 | 3.2 | 5.5 | 232.1 | 234 | 134 | 125 | 30 | 83 | 142 | 5 | 0 | 0 | 1 | 13 | 4 | 2 | 4.58 |
| CL | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 78 | 0 | 4 | 2 | 2.17 | .240 | 0.90 | 5.8 | 2.3 | 8.7 | 62.1 | 40 | 18 | 15 | 5 | 16 | 60 | 0 | 13 | 3 | 0 | 0 | 3 | 9 | 3.03 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 84 | 0 | 1 | 2 | 3.10 | .271 | 1.09 | 8.2 | 1.7 | 8.1 | 87.0 | 79 | 32 | 30 | 9 | 16 | 78 | 0 | 4 | 3 | 0 | 0 | 2 | 3 | 3.17 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 81 | 0 | 3 | 11 | 3.72 | .305 | 1.30 | 7.5 | 4.3 | 9.5 | 67.2 | 56 | 33 | 28 | 6 | 32 | 71 | 0 | 21 | 6 | 0 | 0 | 1 | 1 | 3.52 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 67 | 0 | 5 | 2 | 3.46 | .267 | 1.09 | 7.5 | 2.4 | 8.5 | 67.2 | 56 | 26 | 26 | 8 | 18 | 63 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.48 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 44 | 0 | 8 | 1 | 2.87 | .284 | 1.19 | 8.0 | 2.7 | 9.2 | 47.0 | 42 | 17 | 15 | 6 | 14 | 48 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.51 |