| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 35 | 35 | 17 | 13 | 3.44 | .283 | 1.17 | 7.2 | 3.4 | 7.2 | 279.2 | 222 | 109 | 107 | 22 | 106 | 223 | 7 | 0 | 0 | 2 | 21 | 3 | 4 | 3.60 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 60 | 33 | 33 | 12 | 12 | 5.03 | .326 | 1.41 | 7.9 | 4.8 | 7.3 | 200.1 | 176 | 114 | 112 | 21 | 106 | 163 | 0 | 0 | 0 | 0 | 11 | 9 | 5 | 4.46 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 32 | 32 | 12 | 12 | 4.81 | .323 | 1.41 | 8.0 | 4.7 | 7.0 | 230.1 | 204 | 128 | 123 | 23 | 121 | 180 | 3 | 0 | 0 | 1 | 15 | 4 | 16 | 4.37 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 90 | 0 | 4 | 1 | 3.15 | .296 | 1.25 | 9.8 | 1.5 | 7.6 | 91.1 | 99 | 33 | 32 | 4 | 15 | 77 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.41 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 35 | 0 | 2 | 1 | 1.32 | .287 | 1.15 | 5.6 | 4.8 | 7.7 | 34.0 | 21 | 6 | 5 | 3 | 18 | 29 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 4.21 |
| RP | Rhodes, A.Rhodes, Arthur # >> | 32 | 2001 | L | 64 | 90 | 0 | 5 | 3 | 5.12 | .293 | 1.22 | 8.9 | 2.1 | 8.6 | 65.0 | 64 | 37 | 37 | 10 | 15 | 62 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 3.88 |
| CL | McGraw, T.McGraw, Tug † >> | 36 | 1980 | L | 50 | 55 | 0 | 2 | 6 | 4.01 | .312 | 1.34 | 8.8 | 3.3 | 5.7 | 49.1 | 48 | 24 | 22 | 7 | 18 | 31 | 0 | 37 | 6 | 0 | 0 | 1 | 0 | 4.76 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 3 | 0 | 1 | 0 | 0.00 | .200 | 0.75 | 9.0 | 0.0 | 9.0 | 1.1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 36 | 9 | 0 | 0 | 2 | 4.00 | .308 | 1.33 | 7.0 | 5.0 | 12.0 | 9.0 | 7 | 4 | 4 | 0 | 5 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.00 |