| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 13 | 13 | 7 | 4 | 2.99 | .260 | 1.03 | 7.9 | 1.4 | 5.4 | 105.1 | 92 | 37 | 35 | 8 | 16 | 63 | 6 | 0 | 0 | 0 | 10 | 3 | 0 | 3.33 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 13 | 13 | 5 | 7 | 4.56 | .312 | 1.31 | 8.9 | 3.0 | 7.4 | 94.2 | 93 | 50 | 48 | 12 | 31 | 77 | 3 | 0 | 0 | 0 | 6 | 5 | 0 | 4.17 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 11 | 11 | 2 | 5 | 4.95 | .308 | 1.31 | 9.5 | 2.4 | 4.9 | 72.2 | 76 | 40 | 40 | 9 | 19 | 39 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 4.42 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 13 | 13 | 3 | 5 | 4.42 | .315 | 1.35 | 8.5 | 3.7 | 6.6 | 95.2 | 90 | 49 | 47 | 6 | 39 | 70 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 3.67 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 38 | 0 | 2 | 6 | 5.32 | .283 | 1.18 | 7.7 | 3.1 | 7.5 | 47.1 | 40 | 29 | 28 | 10 | 16 | 39 | 0 | 5 | 6 | 0 | 0 | 0 | 1 | 5.13 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 23 | 0 | 2 | 2 | 2.51 | .271 | 1.11 | 6.8 | 3.4 | 9.6 | 32.1 | 24 | 11 | 9 | 3 | 12 | 34 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.22 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 16 | 0 | 3 | 3 | 6.75 | .348 | 1.60 | 9.5 | 5.0 | 6.3 | 20.0 | 21 | 15 | 15 | 2 | 11 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.55 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 15 | 0 | 2 | 0 | 4.02 | .299 | 1.21 | 7.8 | 3.6 | 3.6 | 15.2 | 13 | 8 | 7 | 3 | 6 | 6 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 6.20 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 7 | 0 | 0 | 0 | 7.50 | .419 | 2.17 | 10.5 | 9.0 | 10.5 | 6.0 | 7 | 6 | 5 | 0 | 6 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 8 | 0 | 0 | 1 | 1.17 | .281 | 1.17 | 7.7 | 3.9 | 12.9 | 7.2 | 6 | 2 | 1 | 1 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.29 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 3 | 2 | 0 | 0 | 13.50 | .451 | 2.46 | 20.0 | 3.0 | 4.0 | 9.1 | 20 | 14 | 14 | 4 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.89 |