| SP | Scherzer, M.Scherzer, Max >> | 25 | 2021 | R | 92 | 27 | 27 | 8 | 11 | 3.98 | .277 | 1.14 | 8.2 | 2.1 | 7.9 | 192.1 | 174 | 95 | 85 | 24 | 45 | 169 | 2 | 0 | 0 | 1 | 15 | 2 | 2 | 3.60 |
| SP | Nelson, R.Nelson, Roger >> | 25 | 1972 | R | 75 | 27 | 27 | 7 | 13 | 7.16 | .354 | 1.63 | 11.1 | 3.6 | 5.2 | 152.0 | 187 | 125 | 121 | 37 | 61 | 87 | 1 | 0 | 0 | 0 | 5 | 2 | 6 | 6.26 |
| SP | Verlander, J.Verlander, Justin # >> | 25 | 2011 | R | 64 | 27 | 27 | 11 | 11 | 5.54 | .315 | 1.36 | 9.5 | 2.7 | 7.8 | 198.1 | 210 | 131 | 122 | 38 | 60 | 171 | 11 | 0 | 0 | 1 | 8 | 3 | 0 | 4.72 |
| SP | Driscoll, D.Driscoll, Denny >> | 25 | 1882 | L | 44 | 26 | 26 | 7 | 13 | 6.10 | .335 | 1.48 | 10.8 | 2.6 | 3.7 | 190.1 | 227 | 147 | 129 | 55 | 54 | 78 | 9 | 0 | 0 | 1 | 5 | 7 | 0 | 6.91 |
| RP | Mayers, M.Mayers, Mike >> | 25 | 2020 | R | 86 | 45 | 0 | 7 | 3 | 3.51 | .270 | 1.07 | 5.7 | 4.0 | 7.4 | 66.2 | 42 | 27 | 26 | 12 | 29 | 54 | 0 | 5 | 3 | 0 | 0 | 3 | 0 | 5.18 |
| RP | Cordero, J.Cordero, Jimmy >> | 25 | 2019 | R | 64 | 31 | 0 | 5 | 2 | 4.47 | .300 | 1.26 | 6.9 | 4.5 | 6.9 | 48.1 | 37 | 24 | 24 | 9 | 24 | 37 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 5.46 |
| RP | Rodney, F.Rodney, Fernando >> | 25 | 2012 | R | 54 | 12 | 0 | 2 | 1 | 3.38 | .304 | 1.25 | 8.4 | 2.8 | 9.0 | 16.0 | 15 | 7 | 6 | 0 | 5 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.13 |
| RP | Spooneybarger, T.Spooneybarger, Tim >> | 25 | 2003 | R | 48 | 1 | 0 | 0 | 0 | - | 1.000 | - | - | - | - | 0.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Romano, J.Romano, Jordan >> | 25 | 2021 | R | 24 | 11 | 0 | 0 | 0 | 7.04 | .361 | 1.70 | 10.2 | 5.4 | 7.2 | 15.1 | 17 | 12 | 12 | 3 | 9 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.80 |