| SP | Gibson, B.Gibson, Bob >> | 33 | 1968 | R | 98 | 5 | 5 | 3 | 1 | 4.03 | .278 | 1.16 | 8.5 | 1.9 | 6.6 | 38.0 | 36 | 17 | 17 | 0 | 8 | 28 | 2 | 0 | 0 | 0 | 3 | 0 | 1 | 2.16 |
| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 96 | 5 | 5 | 0 | 2 | 6.03 | .373 | 1.72 | 11.0 | 4.6 | 7.3 | 31.1 | 38 | 22 | 21 | 1 | 16 | 25 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 3.55 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 93 | 4 | 4 | 4 | 0 | 4.70 | .343 | 1.57 | 12.0 | 2.4 | 4.2 | 30.2 | 40 | 19 | 16 | 6 | 8 | 14 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 5.47 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 82 | 4 | 4 | 3 | 1 | 2.84 | .296 | 1.23 | 7.5 | 3.8 | 6.4 | 31.2 | 26 | 11 | 10 | 3 | 13 | 22 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.19 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 83 | 5 | 5 | 2 | 3 | 5.81 | .301 | 1.29 | 8.7 | 2.9 | 4.1 | 31.0 | 30 | 21 | 20 | 8 | 10 | 14 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6.42 |
| RP | Nathan, J.Nathan, Joe >> | 32 | 2006 | R | 95 | 17 | 0 | 1 | 1 | 6.32 | .338 | 1.47 | 10.8 | 3.0 | 6.0 | 15.2 | 18 | 13 | 11 | 2 | 5 | 10 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 4.60 |
| RP | Putz, J.Putz, J.J. >> | 30 | 2007 | R | 97 | 10 | 0 | 0 | 0 | 2.63 | .196 | 0.73 | 4.8 | 2.1 | 9.0 | 13.2 | 7 | 4 | 4 | 3 | 3 | 13 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.69 |
| RP | Bautista, F.Bautista, Félix + >> | 28 | 2023 | R | 83 | 6 | 0 | 0 | 1 | 3.86 | .250 | 1.00 | 5.1 | 3.9 | 12.9 | 7.0 | 4 | 3 | 3 | 0 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.43 |
| RP | Meredith, C.Meredith, Cla + >> | 23 | 2006 | R | 85 | 5 | 0 | 0 | 0 | 15.00 | .500 | 3.00 | 15.0 | 12.0 | 3.0 | 3.0 | 5 | 5 | 5 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.33 |
| RP | McGee, J.McGee, Jake + >> | 27 | 2014 | L | 70 | 2 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 6.0 | 0.0 | 3.0 | 3.1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |
| RP | Rhodes, A.Rhodes, Arthur + >> | 32 | 2001 | L | 74 | 1 | 0 | 0 | 1 | 13.50 | .600 | 4.50 | - | - | - | 0.2 | 1 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 90 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Diaz, A.Diaz, Alexis + >> | 25 | 2022 | R | 76 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Cicotte, E.Cicotte, Eddie + >> | 33 | 1917 | R | 85 | 1 | 1 | 0 | 1 | 11.57 | .440 | 2.36 | 22.5 | 2.3 | 2.3 | 4.2 | 10 | 6 | 6 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13.00 |
| CL | Hader, J.Hader, Josh >> | 27 | 2021 | L | 95 | 11 | 0 | 0 | 2 | 5.91 | .333 | 1.50 | 7.2 | 7.2 | 15.3 | 10.2 | 8 | 7 | 7 | 1 | 8 | 17 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Gossage, R.Gossage, Rich + >> | 26 | 1977 | R | 70 | 1 | 0 | 0 | 0 | 13.50 | .500 | 3.00 | - | - | - | 0.2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Reulbach, E.Reulbach, Ed + >> | 23 | 1905 | R | 81 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Betancourt, R.Betancourt, Rafael + >> | 32 | 2007 | R | 83 | 2 | 0 | 0 | 0 | 6.75 | .333 | 1.50 | 13.5 | 4.5 | 9.0 | 2.2 | 3 | 2 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Parker, B.Parker, Blake + >> | 32 | 2017 | R | 87 | 3 | 0 | 0 | 0 | 0.00 | .231 | 0.90 | 3.0 | 6.0 | 15.0 | 3.1 | 1 | 0 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.67 |
| SP | Chesbro, J.Chesbro, Jack + >> | 30 | 1904 | R | 80 | 1 | 1 | 0 | 1 | 2.35 | .303 | 1.30 | 7.7 | 5.1 | 9.0 | 7.2 | 6 | 2 | 2 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2.71 |
| SP | Brown, M.Brown, Mordecai + >> | 33 | 1909 | R | 87 | 2 | 2 | 0 | 1 | 4.91 | .267 | 1.09 | 6.4 | 3.9 | 4.5 | 14.2 | 10 | 8 | 8 | 2 | 6 | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.14 |
| SP | Siebert, S.Siebert, Sonny + >> | 28 | 1965 | R | 80 | 1 | 1 | 0 | 0 | 1.29 | .125 | 0.43 | 3.9 | 0.0 | 7.7 | 7.0 | 3 | 1 | 1 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.14 |
| SP | Higuera, T.Higuera, Teddy + >> | 30 | 1988 | L | 73 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |