| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 99 | 9 | 9 | 4 | 4 | 4.09 | .307 | 1.33 | 10.1 | 1.8 | 4.6 | 55.0 | 62 | 25 | 25 | 3 | 11 | 28 | 1 | 0 | 0 | 1 | 4 | 0 | 1 | 3.29 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 85 | 8 | 8 | 1 | 6 | 7.93 | .351 | 1.57 | 9.5 | 4.8 | 5.5 | 36.1 | 38 | 32 | 32 | 8 | 19 | 22 | 1 | 0 | 0 | 0 | 3 | 2 | 4 | 6.42 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 91 | 8 | 8 | 5 | 2 | 3.62 | .299 | 1.26 | 8.2 | 3.3 | 3.5 | 54.2 | 49 | 24 | 22 | 5 | 20 | 21 | 3 | 0 | 0 | 0 | 5 | 1 | 1 | 4.59 |
| SP | Chance, D.Chance, Dean >> | 26 | 1967 | R | 60 | 8 | 8 | 3 | 3 | 4.87 | .332 | 1.49 | 10.0 | 3.5 | 5.1 | 44.1 | 49 | 25 | 24 | 4 | 17 | 25 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 4.20 |
| SP | Strasburg, S.Strasburg, Stephen >> | 26 | 2015 | R | 58 | 8 | 8 | 3 | 4 | 4.07 | .308 | 1.33 | 9.4 | 2.6 | 7.3 | 42.0 | 44 | 21 | 19 | 5 | 12 | 34 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 3.79 |
| RP | Guerrier, M.Guerrier, Matt >> | 31 | 2009 | R | 76 | 21 | 0 | 1 | 0 | 3.81 | .254 | 0.99 | 7.7 | 1.3 | 4.8 | 28.1 | 24 | 12 | 12 | 2 | 4 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3.39 |
| RP | Helsley, R.Helsley, Ryan >> | 29 | 2024 | R | 71 | 19 | 0 | 1 | 0 | 3.80 | .312 | 1.36 | 8.1 | 4.3 | 9.9 | 21.1 | 19 | 11 | 9 | 2 | 10 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.48 |
| RP | Perkins, G.Perkins, Glen >> | 29 | 2012 | L | 69 | 20 | 0 | 0 | 0 | 4.71 | .315 | 1.38 | 11.6 | 0.9 | 8.6 | 21.0 | 27 | 12 | 11 | 2 | 2 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.62 |
| CL | Clippard, T.Clippard, Tyler >> | 29 | 2014 | R | 85 | 16 | 0 | 0 | 0 | 2.12 | .261 | 1.00 | 5.8 | 3.2 | 7.4 | 17.0 | 11 | 4 | 4 | 1 | 6 | 14 | 0 | 11 | 1 | 0 | 0 | 1 | 0 | 3.35 |
| RP | Broxton, J.Broxton, Jonathan >> | 26 | 2010 | R | 19 | 18 | 0 | 1 | 0 | 3.10 | .265 | 1.08 | 7.7 | 2.3 | 7.7 | 20.1 | 17 | 7 | 7 | 2 | 5 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.35 |