| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 94 | 19 | 19 | 10 | 5 | 2.49 | .280 | 1.15 | 5.9 | 4.4 | 4.0 | 134.0 | 88 | 41 | 37 | 8 | 66 | 59 | 2 | 0 | 0 | 2 | 14 | 2 | 1 | 4.42 |
| SP | Strasburg, S.Strasburg, Stephen >> | 22 | 2011 | R | 100 | 16 | 16 | 6 | 3 | 3.06 | .290 | 1.21 | 8.9 | 2.1 | 8.3 | 79.1 | 78 | 34 | 27 | 3 | 18 | 73 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 2.37 |
| SP | Fisher, E.Fisher, Eddie >> | 24 | 1960 | R | 72 | 17 | 17 | 4 | 8 | 5.05 | .326 | 1.42 | 10.6 | 2.3 | 4.6 | 67.2 | 79 | 43 | 38 | 4 | 17 | 34 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 3.61 |
| SP | Verlander, J.Verlander, Justin >> | 24 | 2007 | R | 63 | 17 | 17 | 7 | 9 | 4.87 | .334 | 1.51 | 9.1 | 4.4 | 7.2 | 85.0 | 86 | 48 | 46 | 4 | 42 | 68 | 0 | 0 | 0 | 0 | 8 | 0 | 4 | 3.49 |
| SP | Chance, D.Chance, Dean >> | 22 | 1963 | R | 44 | 17 | 16 | 8 | 5 | 3.61 | .310 | 1.35 | 9.0 | 3.2 | 5.6 | 84.2 | 84 | 41 | 34 | 8 | 30 | 52 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.07 |
| RP | Clippard, T.Clippard, Tyler >> | 25 | 2010 | R | 65 | 47 | 0 | 4 | 2 | 3.60 | .355 | 1.62 | 9.0 | 5.6 | 10.0 | 55.0 | 55 | 27 | 22 | 2 | 34 | 61 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 3.22 |
| RP | Broxton, J.Broxton, Jonathan >> | 22 | 2006 | R | 58 | 46 | 0 | 2 | 2 | 6.39 | .295 | 1.26 | 7.0 | 4.4 | 8.1 | 49.1 | 38 | 35 | 35 | 5 | 24 | 44 | 0 | 5 | 0 | 0 | 0 | 0 | 3 | 4.00 |
| RP | Helsley, R.Helsley, Ryan >> | 25 | 2020 | R | 53 | 37 | 0 | 1 | 0 | 4.73 | .358 | 1.60 | 9.2 | 5.2 | 5.0 | 40.0 | 41 | 24 | 21 | 3 | 23 | 22 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.83 |
| RP | McMahon, D.McMahon, Don >> | 28 | 1958 | R | 30 | 30 | 0 | 1 | 1 | 5.03 | .379 | 1.81 | 8.8 | 7.6 | 4.4 | 39.1 | 38 | 23 | 22 | 2 | 33 | 19 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.31 |
| SP | Perez, P.Perez, Pascual >> | 25 | 1982 | R | 30 | 14 | 2 | 0 | 1 | 10.80 | .444 | 2.26 | 16.3 | 4.7 | 6.9 | 21.2 | 38 | 26 | 26 | 3 | 11 | 16 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 5.33 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 95 | 35 | 0 | 1 | 2 | 2.55 | .235 | 0.87 | 6.4 | 1.5 | 8.1 | 42.1 | 30 | 13 | 12 | 3 | 7 | 38 | 0 | 14 | 1 | 0 | 0 | 2 | 1 | 2.76 |