| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 97 | 19 | 19 | 8 | 5 | 3.53 | .285 | 1.19 | 8.1 | 2.7 | 5.0 | 132.2 | 119 | 57 | 52 | 6 | 39 | 74 | 3 | 0 | 0 | 1 | 12 | 1 | 4 | 3.38 |
| SP | Waddell, R.Waddell, Rube >> | 24 | 1900 | L | 76 | 18 | 18 | 9 | 7 | 3.80 | .284 | 1.18 | 8.2 | 2.5 | 4.8 | 118.1 | 107 | 50 | 50 | 10 | 33 | 63 | 1 | 0 | 0 | 0 | 12 | 1 | 1 | 3.90 |
| SP | Drysdale, D.Drysdale, Don >> | 21 | 1957 | R | 67 | 17 | 17 | 7 | 3 | 3.01 | .262 | 1.04 | 6.7 | 2.7 | 5.2 | 116.2 | 86 | 43 | 39 | 8 | 35 | 67 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 3.72 |
| SP | Johnson, R.Johnson, Randy >> | 27 | 1990 | L | 54 | 17 | 17 | 4 | 9 | 3.97 | .313 | 1.34 | 8.5 | 3.7 | 5.5 | 99.2 | 93 | 58 | 44 | 12 | 41 | 61 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 4.65 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 91 | 48 | 0 | 6 | 0 | 0.74 | .207 | 0.76 | 3.9 | 3.0 | 6.9 | 48.2 | 21 | 4 | 4 | 0 | 16 | 37 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.52 |
| RP | Marte, D.Marte, Damaso >> | 27 | 2002 | L | 79 | 48 | 0 | 2 | 3 | 3.21 | .303 | 1.31 | 7.9 | 4.1 | 8.2 | 33.2 | 29 | 13 | 12 | 2 | 15 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.33 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 98 | 39 | 0 | 5 | 2 | 0.78 | .219 | 0.84 | 5.3 | 2.3 | 7.6 | 46.1 | 27 | 8 | 4 | 1 | 12 | 39 | 0 | 24 | 2 | 0 | 0 | 0 | 0 | 2.37 |
| SU | Romano, J.Romano, Jordan >> | 27 | 2020 | R | 96 | 37 | 0 | 0 | 0 | 1.98 | .201 | 0.73 | 4.0 | 2.6 | 9.4 | 41.0 | 18 | 9 | 9 | 0 | 12 | 43 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 1.85 |
| RP | Foulke, K.Foulke, Keith >> | 26 | 1998 | R | 67 | 26 | 0 | 2 | 0 | 2.42 | .235 | 0.92 | 5.9 | 2.4 | 7.6 | 26.0 | 17 | 7 | 7 | 0 | 7 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2.12 |