| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 96 | 21 | 21 | 6 | 9 | 3.30 | .286 | 1.17 | 7.8 | 2.8 | 4.5 | 155.2 | 134 | 70 | 57 | 9 | 48 | 78 | 5 | 0 | 0 | 0 | 15 | 5 | 4 | 3.77 |
| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 85 | 21 | 21 | 5 | 13 | 6.17 | .330 | 1.48 | 9.4 | 3.9 | 5.9 | 112.1 | 117 | 77 | 77 | 10 | 49 | 74 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 4.15 |
| SP | Zambrano, C.Zambrano, Carlos >> | 25 | 2006 | R | 48 | 20 | 20 | 8 | 7 | 3.27 | .300 | 1.27 | 6.0 | 5.5 | 6.1 | 123.2 | 82 | 49 | 45 | 6 | 75 | 83 | 0 | 0 | 0 | 0 | 13 | 2 | 4 | 4.16 |
| RP | Percival, T.Percival, Troy >> | 30 | 1999 | R | 78 | 50 | 0 | 3 | 2 | 2.70 | .283 | 1.15 | 6.7 | 3.7 | 7.6 | 63.1 | 47 | 22 | 19 | 3 | 26 | 53 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 3.27 |
| RP | Thigpen, B.Thigpen, Bobby >> | 27 | 1990 | R | 74 | 45 | 0 | 3 | 2 | 2.15 | .230 | 0.89 | 4.9 | 3.2 | 6.3 | 50.1 | 27 | 12 | 12 | 2 | 18 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.20 |
| RP | Hough, C.Hough, Charlie >> | 26 | 1974 | R | 68 | 28 | 0 | 2 | 3 | 2.57 | .296 | 1.21 | 7.1 | 3.9 | 5.4 | 42.0 | 33 | 16 | 12 | 1 | 18 | 25 | 0 | 2 | 1 | 0 | 0 | 2 | 6 | 3.55 |
| RP | Jansen, K.Jansen, Kenley >> | 26 | 2014 | R | 59 | 15 | 0 | 1 | 0 | 0.57 | .203 | 0.70 | 5.4 | 1.2 | 8.4 | 15.2 | 9 | 2 | 1 | 0 | 2 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1.73 |
| CL | Holland, G.Holland, Greg † >> | 28 | 2014 | R | 93 | 38 | 0 | 1 | 2 | 1.76 | .276 | 1.10 | 6.6 | 3.3 | 9.0 | 41.0 | 30 | 9 | 8 | 2 | 15 | 41 | 0 | 23 | 2 | 0 | 0 | 2 | 4 | 2.88 |
| RP | Rosenthal, T.Rosenthal, Trevor >> | 26 | 2016 | R | 9 | 13 | 0 | 0 | 1 | 4.29 | .382 | 1.86 | 10.3 | 6.4 | 9.4 | 21.0 | 24 | 11 | 10 | 1 | 15 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| SP | Blyleven, B.Blyleven, Bert >> | 23 | 1974 | R | 56 | 10 | 0 | 0 | 0 | 3.47 | .305 | 1.28 | 8.4 | 3.1 | 3.9 | 49.1 | 46 | 20 | 19 | 2 | 17 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.84 |