| SP | Ohka, T.Ohka, Tomokazu # >> | 31 | 2000 | R | 62 | 35 | 35 | 12 | 13 | 4.75 | .324 | 1.42 | 9.7 | 3.0 | 6.9 | 219.2 | 237 | 137 | 116 | 28 | 74 | 169 | 0 | 0 | 0 | 0 | 18 | 5 | 3 | 4.20 |
| SP | Wakefield, T.Wakefield, Tim # >> | 41 | 2002 | R | 49 | 33 | 33 | 3 | 15 | 5.70 | .350 | 1.60 | 10.3 | 4.1 | 6.3 | 115.1 | 131 | 83 | 73 | 19 | 53 | 81 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 5.17 |
| SP | Gabbard, K.Gabbard, Kason # >> | 25 | 2007 | L | 37 | 29 | 29 | 7 | 12 | 5.50 | .357 | 1.62 | 9.8 | 4.8 | 5.8 | 142.1 | 155 | 105 | 87 | 22 | 76 | 91 | 0 | 0 | 0 | 0 | 7 | 6 | 7 | 5.46 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 27 | 2007 | R | 34 | 20 | 20 | 4 | 13 | 6.90 | .382 | 1.81 | 11.1 | 5.2 | 8.2 | 103.0 | 127 | 83 | 79 | 17 | 59 | 94 | 0 | 0 | 0 | 0 | 9 | 5 | 3 | 5.18 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2006 | R | 98 | 55 | 0 | 3 | 4 | 1.91 | .261 | 1.02 | 7.4 | 1.9 | 11.7 | 56.2 | 46 | 16 | 12 | 4 | 12 | 73 | 0 | 36 | 2 | 0 | 0 | 2 | 0 | 2.07 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 79 | 88 | 0 | 2 | 5 | 3.01 | .260 | 1.03 | 7.2 | 2.2 | 7.3 | 95.2 | 76 | 33 | 32 | 10 | 23 | 77 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 3.54 |
| RP | Durocher, J.Durocher, Jayson >> | 33 | 2002 | R | 70 | 72 | 0 | 4 | 2 | 2.83 | .277 | 1.13 | 5.7 | 4.6 | 9.6 | 57.1 | 36 | 18 | 18 | 6 | 29 | 61 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.81 |
| RP | Graves, D.Graves, Danny >> | 34 | 1996 | R | 60 | 67 | 0 | 3 | 1 | 3.94 | .321 | 1.38 | 8.5 | 4.0 | 7.4 | 77.2 | 73 | 35 | 34 | 10 | 34 | 63 | 0 | 1 | 3 | 0 | 0 | 3 | 2 | 4.49 |
| RP | Timlin, M.Timlin, Mike >> | 41 | 2007 | R | 53 | 38 | 0 | 1 | 0 | 4.13 | .280 | 1.16 | 7.4 | 3.2 | 4.5 | 28.1 | 23 | 15 | 13 | 4 | 10 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.93 |
| RP | Fossum, C.Fossum, Casey >> | 29 | 2002 | L | 52 | 82 | 0 | 3 | 3 | 3.82 | .280 | 1.13 | 8.8 | 1.4 | 9.4 | 75.1 | 73 | 37 | 32 | 15 | 12 | 78 | 0 | 3 | 2 | 0 | 0 | 3 | 2 | 4.12 |
| SP | Millwood, K.Millwood, Kevin >> | 33 | 1997 | R | 76 | 12 | 8 | 5 | 5 | 3.33 | .296 | 1.22 | 9.2 | 1.8 | 8.4 | 46.0 | 47 | 25 | 17 | 7 | 9 | 43 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 3.83 |