| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 28 | 28 | 14 | 12 | 3.89 | .285 | 1.18 | 8.6 | 2.0 | 3.8 | 196.2 | 188 | 86 | 85 | 20 | 44 | 82 | 4 | 0 | 0 | 0 | 15 | 3 | 6 | 4.21 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 27 | 27 | 12 | 10 | 3.28 | .269 | 1.08 | 8.2 | 1.6 | 5.3 | 197.2 | 179 | 76 | 72 | 22 | 35 | 117 | 7 | 0 | 0 | 2 | 19 | 4 | 3 | 3.86 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 27 | 27 | 13 | 7 | 3.10 | .278 | 1.10 | 8.5 | 1.5 | 5.9 | 197.2 | 185 | 69 | 68 | 14 | 32 | 130 | 7 | 0 | 0 | 2 | 18 | 11 | 3 | 3.26 |
| RP | Devine, J.Devine, Joey † >> | 25 | 2008 | R | 81 | 66 | 0 | 4 | 1 | 2.56 | .261 | 1.03 | 5.5 | 3.9 | 8.8 | 77.1 | 47 | 22 | 22 | 6 | 33 | 75 | 0 | 15 | 5 | 0 | 0 | 2 | 0 | 3.43 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 46 | 0 | 3 | 5 | 3.00 | .254 | 1.02 | 6.4 | 2.8 | 7.2 | 51.0 | 36 | 17 | 17 | 4 | 16 | 41 | 0 | 6 | 1 | 0 | 0 | 0 | 1 | 3.35 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 19 | 0 | 1 | 2 | 3.79 | .288 | 1.21 | 7.1 | 3.8 | 8.1 | 19.0 | 15 | 8 | 8 | 2 | 8 | 17 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.84 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 11 | 0 | 1 | 1 | 1.64 | .327 | 1.45 | 8.2 | 4.9 | 7.4 | 11.0 | 10 | 2 | 2 | 1 | 6 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 3 | 0 | 0 | 1 | 3.00 | .400 | 2.00 | 9.0 | 9.0 | 12.0 | 3.0 | 3 | 1 | 1 | 0 | 3 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 16 | 0 | 0 | 0 | 1.74 | .235 | 0.87 | 4.5 | 3.6 | 7.2 | 20.2 | 10 | 6 | 4 | 4 | 8 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.35 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 14 | 1 | 6 | 2 | 2.45 | .271 | 1.08 | 7.0 | 2.8 | 5.6 | 80.2 | 62 | 23 | 22 | 7 | 25 | 50 | 1 | 0 | 0 | 0 | 1 | 3 | 1 | 3.94 |