| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 14 | 14 | 6 | 3 | 2.71 | .242 | 0.95 | 5.7 | 2.9 | 5.7 | 89.2 | 56 | 27 | 27 | 6 | 29 | 56 | 0 | 0 | 0 | 0 | 11 | 1 | 0 | 3.63 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 14 | 14 | 5 | 5 | 2.68 | .261 | 1.04 | 6.7 | 2.7 | 6.6 | 107.1 | 80 | 34 | 32 | 11 | 32 | 78 | 3 | 0 | 0 | 1 | 11 | 2 | 0 | 3.83 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 14 | 13 | 8 | 2 | 3.82 | .301 | 1.26 | 6.4 | 5.0 | 3.8 | 94.1 | 67 | 42 | 40 | 6 | 52 | 40 | 2 | 0 | 0 | 0 | 7 | 3 | 0 | 4.73 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 36 | 0 | 6 | 2 | 2.37 | .264 | 1.07 | 5.3 | 4.4 | 7.5 | 49.1 | 29 | 13 | 13 | 3 | 24 | 41 | 0 | 6 | 4 | 0 | 0 | 0 | 2 | 3.59 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 29 | 0 | 1 | 2 | 1.25 | .234 | 0.92 | 4.3 | 4.0 | 9.0 | 36.0 | 17 | 6 | 5 | 2 | 16 | 36 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.06 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 21 | 0 | 1 | 0 | 2.08 | .257 | 1.00 | 6.2 | 2.8 | 8.0 | 26.0 | 18 | 7 | 6 | 0 | 8 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 2.27 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 14 | 0 | 5 | 0 | 1.62 | .180 | 0.60 | 2.3 | 3.4 | 9.0 | 16.2 | 4 | 3 | 3 | 0 | 6 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.31 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 7 | 0 | 1 | 1 | 0.84 | .200 | 0.75 | 5.4 | 1.8 | 5.4 | 10.2 | 6 | 1 | 1 | 0 | 2 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.40 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 53 | 2 | 0 | 0 | 0 | 6.00 | .308 | 1.33 | 9.0 | 3.0 | 9.0 | 3.0 | 3 | 2 | 2 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.33 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 48 | 6 | 0 | 0 | 1 | 7.56 | .405 | 2.04 | 13.5 | 5.6 | 6.8 | 8.1 | 12 | 7 | 7 | 2 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.63 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 5 | 0 | 2 | 0 | 5.24 | .316 | 1.34 | 8.6 | 3.7 | 2.5 | 22.1 | 21 | 13 | 13 | 3 | 9 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.59 |