| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 29 | 29 | 10 | 10 | 3.38 | .263 | 1.06 | 7.5 | 2.0 | 9.9 | 202.1 | 169 | 76 | 76 | 20 | 45 | 222 | 2 | 0 | 0 | 1 | 20 | 3 | 0 | 2.80 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 8 | 13 | 3.49 | .288 | 1.19 | 7.5 | 3.3 | 8.5 | 193.2 | 160 | 80 | 75 | 17 | 71 | 182 | 1 | 0 | 0 | 0 | 21 | 4 | 6 | 3.42 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 71 | 27 | 27 | 7 | 17 | 4.42 | .298 | 1.25 | 8.5 | 2.8 | 8.3 | 185.1 | 174 | 97 | 91 | 22 | 58 | 170 | 2 | 0 | 0 | 2 | 13 | 4 | 4 | 3.71 |
| SP | Hendrix, C.Hendrix, Claude † >> | 25 | 1914 | R | 69 | 27 | 27 | 11 | 7 | 3.59 | .295 | 1.23 | 8.6 | 2.5 | 3.8 | 190.1 | 182 | 83 | 76 | 13 | 53 | 80 | 4 | 0 | 0 | 1 | 17 | 4 | 2 | 3.95 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 77 | 0 | 4 | 5 | 3.66 | .272 | 1.11 | 6.6 | 3.4 | 9.9 | 98.1 | 72 | 47 | 40 | 13 | 37 | 108 | 0 | 9 | 3 | 0 | 0 | 1 | 4 | 3.68 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 54 | 0 | 3 | 0 | 2.01 | .255 | 1.02 | 4.8 | 4.6 | 8.2 | 53.2 | 28 | 12 | 12 | 1 | 27 | 48 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 2.96 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 35 | 0 | 4 | 3 | 2.27 | .292 | 1.21 | 8.4 | 2.7 | 8.4 | 43.2 | 40 | 11 | 11 | 4 | 13 | 40 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.33 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 25 | 0 | 5 | 1 | 2.15 | .254 | 1.02 | 6.8 | 2.5 | 9.0 | 29.1 | 22 | 7 | 7 | 2 | 8 | 29 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.72 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 15 | 0 | 1 | 3 | 3.86 | .310 | 1.29 | 9.0 | 2.8 | 11.3 | 16.1 | 16 | 7 | 7 | 2 | 5 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.25 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 3 | 0 | 0 | 1 | 10.13 | .467 | 2.63 | 31.5 | 0.0 | 4.5 | 2.2 | 7 | 3 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.50 |