| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 14 | 14 | 4 | 3 | 4.33 | .302 | 1.28 | 9.2 | 2.4 | 4.1 | 95.2 | 97 | 50 | 46 | 10 | 25 | 43 | 1 | 0 | 0 | 1 | 7 | 2 | 1 | 4.32 |
| SP | Darvish, Y.Darvish, Yu # >> | 26 | 2013 | R | 46 | 13 | 13 | 4 | 4 | 5.22 | .334 | 1.47 | 9.2 | 4.0 | 8.8 | 81.0 | 83 | 51 | 47 | 10 | 36 | 79 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 4.10 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 39 | 0 | 2 | 1 | 4.73 | .297 | 1.24 | 7.6 | 3.7 | 7.9 | 32.1 | 27 | 18 | 17 | 5 | 13 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.59 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 13 | 0 | 2 | 2 | 4.38 | .302 | 1.22 | 8.3 | 3.0 | 12.8 | 12.1 | 11 | 6 | 6 | 1 | 4 | 17 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.50 |
| CL | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 30 | 0 | 2 | 3 | 2.29 | .243 | 0.93 | 6.2 | 2.3 | 10.5 | 35.1 | 24 | 13 | 9 | 2 | 9 | 41 | 0 | 14 | 1 | 0 | 0 | 1 | 1 | 2.26 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 11 | 0 | 3 | 1 | 2.18 | .235 | 0.92 | 5.4 | 3.2 | 6.3 | 20.2 | 12 | 5 | 5 | 1 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 36 | 0 | 0 | 2 | 3.68 | .275 | 1.14 | 6.1 | 4.1 | 8.2 | 22.0 | 15 | 10 | 9 | 3 | 10 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.32 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 7 | 1 | 1 | 2 | 4.57 | .381 | 1.80 | 7.7 | 9.0 | 6.4 | 21.2 | 18 | 12 | 11 | 2 | 21 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.95 |