| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 9 | 6 | 2.70 | .245 | 0.96 | 6.3 | 2.4 | 10.6 | 183.1 | 128 | 59 | 55 | 20 | 48 | 216 | 1 | 0 | 0 | 0 | 18 | 2 | 0 | 2.88 |
| SP | McClanahan, S.McClanahan, Shane # >> | 25 | 2022 | L | 90 | 26 | 26 | 7 | 11 | 5.35 | .355 | 1.64 | 10.6 | 4.2 | 9.5 | 149.2 | 176 | 91 | 89 | 30 | 69 | 158 | 0 | 0 | 0 | 0 | 7 | 2 | 5 | 4.93 |
| SP | Buehler, W.Buehler, Walker # >> | 23 | 2018 | R | 84 | 25 | 25 | 10 | 10 | 5.32 | .334 | 1.51 | 9.3 | 4.3 | 8.7 | 142.0 | 146 | 87 | 84 | 26 | 68 | 137 | 0 | 0 | 0 | 0 | 9 | 0 | 5 | 4.89 |
| SP | Millwood, K.Millwood, Kevin # >> | 25 | 1999 | R | 71 | 25 | 25 | 11 | 7 | 5.62 | .337 | 1.50 | 10.2 | 3.4 | 7.5 | 163.1 | 184 | 102 | 102 | 30 | 61 | 135 | 3 | 0 | 0 | 0 | 10 | 4 | 2 | 4.93 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 84 | 0 | 3 | 1 | 3.05 | .306 | 1.29 | 8.4 | 3.2 | 10.7 | 59.0 | 55 | 24 | 20 | 10 | 21 | 70 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.00 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 72 | 0 | 4 | 2 | 3.81 | .301 | 1.26 | 6.9 | 4.4 | 9.7 | 85.0 | 65 | 37 | 36 | 11 | 42 | 92 | 0 | 5 | 3 | 0 | 0 | 3 | 0 | 4.11 |
| RP | Boxberger, B.Boxberger, Brad † $$ >> | 26 | 2014 | R | 82 | 65 | 0 | 7 | 0 | 2.26 | .238 | 0.91 | 4.8 | 3.5 | 10.7 | 75.2 | 40 | 20 | 19 | 5 | 29 | 89 | 0 | 6 | 2 | 0 | 0 | 2 | 5 | 2.73 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 73 | 58 | 0 | 4 | 6 | 3.62 | .307 | 1.33 | 8.2 | 3.9 | 8.3 | 64.2 | 58 | 33 | 26 | 7 | 28 | 59 | 0 | 7 | 3 | 0 | 0 | 0 | 6 | 3.89 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 74 | 50 | 0 | 3 | 0 | 3.40 | .309 | 1.32 | 8.5 | 3.4 | 8.5 | 53.0 | 50 | 23 | 20 | 10 | 20 | 50 | 0 | 5 | 2 | 0 | 0 | 1 | 3 | 4.75 |