| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 14 | 13 | 4.44 | .294 | 1.23 | 8.1 | 3.0 | 9.8 | 213.0 | 192 | 108 | 105 | 35 | 70 | 231 | 4 | 0 | 0 | 1 | 19 | 4 | 0 | 4.01 |
| SP | Flaherty, J.Flaherty, Jack # >> | 23 | 2019 | R | 82 | 33 | 33 | 16 | 10 | 4.29 | .312 | 1.34 | 9.2 | 2.9 | 9.5 | 191.0 | 195 | 93 | 91 | 30 | 61 | 202 | 0 | 0 | 0 | 0 | 18 | 4 | 4 | 3.95 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 32 | 32 | 11 | 11 | 4.85 | .322 | 1.40 | 9.6 | 3.1 | 9.0 | 193.0 | 205 | 105 | 104 | 30 | 66 | 192 | 4 | 0 | 0 | 1 | 16 | 4 | 3 | 4.12 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 79 | 32 | 32 | 16 | 10 | 4.01 | .314 | 1.35 | 8.7 | 3.5 | 6.2 | 231.1 | 223 | 108 | 103 | 33 | 90 | 158 | 12 | 0 | 0 | 3 | 17 | 4 | 10 | 4.71 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 68 | 0 | 2 | 8 | 2.27 | .291 | 1.20 | 5.9 | 5.0 | 8.3 | 67.1 | 44 | 17 | 17 | 5 | 37 | 62 | 0 | 43 | 2 | 0 | 0 | 2 | 3 | 3.87 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 54 | 0 | 0 | 1 | 2.68 | .300 | 1.27 | 9.2 | 2.4 | 7.5 | 53.2 | 54 | 22 | 16 | 8 | 14 | 44 | 0 | 6 | 4 | 0 | 0 | 1 | 0 | 4.15 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 35 | 0 | 4 | 2 | 1.91 | .282 | 1.16 | 7.7 | 2.8 | 10.1 | 42.1 | 36 | 9 | 9 | 4 | 13 | 47 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.00 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 27 | 0 | 5 | 1 | 1.45 | .228 | 0.88 | 4.6 | 3.4 | 8.8 | 37.1 | 19 | 7 | 6 | 2 | 14 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.89 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 69 | 24 | 0 | 1 | 0 | 3.15 | .341 | 1.50 | 8.1 | 5.4 | 5.9 | 20.0 | 18 | 7 | 7 | 2 | 12 | 13 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.95 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 3 | 0 | 0 | 1 | 7.20 | .348 | 1.60 | 9.0 | 5.4 | 7.2 | 5.0 | 5 | 4 | 4 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.20 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 26 | 0 | 1 | 3 | 3.97 | .306 | 1.31 | 9.3 | 2.5 | 8.4 | 113.1 | 117 | 52 | 50 | 12 | 31 | 105 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.40 |