| SP | Martinez, P.Martinez, Pedro $$ >> | 29 | 2000 | R | 100 | 27 | 27 | 8 | 10 | 3.49 | .283 | 1.14 | 7.9 | 2.4 | 9.0 | 183.0 | 161 | 74 | 71 | 24 | 48 | 184 | 8 | 0 | 0 | 3 | 16 | 8 | 1 | 3.61 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 26 | 26 | 5 | 12 | 6.33 | .342 | 1.52 | 10.0 | 3.7 | 7.6 | 113.2 | 126 | 80 | 80 | 19 | 47 | 96 | 0 | 0 | 0 | 0 | 7 | 4 | 7 | 4.84 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 72 | 26 | 26 | 9 | 8 | 4.79 | .323 | 1.41 | 8.5 | 4.3 | 6.9 | 144.2 | 136 | 81 | 77 | 21 | 68 | 110 | 0 | 0 | 0 | 0 | 13 | 3 | 3 | 4.85 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 74 | 25 | 25 | 7 | 10 | 5.12 | .328 | 1.45 | 9.7 | 3.4 | 6.5 | 128.1 | 138 | 75 | 73 | 16 | 48 | 92 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 4.36 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 96 | 52 | 0 | 4 | 11 | 3.83 | .305 | 1.32 | 9.7 | 2.3 | 9.0 | 51.2 | 55 | 22 | 22 | 11 | 13 | 51 | 0 | 24 | 6 | 0 | 0 | 0 | 1 | 4.57 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 94 | 57 | 0 | 0 | 1 | 3.95 | .261 | 1.04 | 6.5 | 3.0 | 10.0 | 54.2 | 39 | 24 | 24 | 7 | 18 | 60 | 0 | 5 | 4 | 0 | 0 | 1 | 1 | 3.52 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 71 | 0 | 4 | 3 | 5.96 | .364 | 1.70 | 9.8 | 5.6 | 8.4 | 45.1 | 49 | 30 | 30 | 10 | 28 | 42 | 0 | 0 | 1 | 0 | 0 | 1 | 8 | 5.96 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 73 | 0 | 6 | 2 | 1.94 | .251 | 1.00 | 5.3 | 3.8 | 11.1 | 69.2 | 41 | 16 | 15 | 7 | 29 | 85 | 0 | 3 | 0 | 0 | 0 | 0 | 3 | 3.12 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 72 | 49 | 0 | 3 | 0 | 2.97 | .264 | 1.06 | 6.0 | 3.6 | 10.4 | 57.2 | 38 | 19 | 19 | 8 | 23 | 66 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.77 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 31 | 0 | 0 | 0 | 4.40 | .264 | 1.04 | 5.4 | 4.2 | 13.2 | 30.2 | 18 | 15 | 15 | 4 | 14 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.30 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 70 | 7 | 0 | 1 | 1 | 2.38 | .292 | 1.15 | 8.2 | 2.5 | 3.3 | 11.1 | 10 | 4 | 3 | 2 | 3 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.73 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 66 | 31 | 0 | 6 | 4 | 3.65 | .277 | 1.12 | 7.7 | 2.4 | 8.7 | 113.1 | 97 | 49 | 46 | 12 | 30 | 109 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 3.33 |