| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 83 | 35 | 35 | 6 | 22 | 6.32 | .339 | 1.50 | 10.2 | 3.3 | 8.0 | 206.1 | 234 | 147 | 145 | 39 | 76 | 184 | 0 | 0 | 0 | 0 | 9 | 8 | 4 | 4.90 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 80 | 32 | 31 | 10 | 16 | 4.84 | .319 | 1.39 | 10.3 | 2.2 | 4.5 | 200.2 | 229 | 117 | 108 | 27 | 49 | 101 | 6 | 0 | 0 | 3 | 14 | 4 | 3 | 4.54 |
| SP | Skenes, P.Skenes, Paul >> | 23 | 2025 | R | 70 | 31 | 29 | 5 | 14 | 4.68 | .312 | 1.33 | 9.3 | 2.8 | 7.8 | 169.1 | 174 | 96 | 88 | 36 | 52 | 146 | 0 | 0 | 0 | 0 | 17 | 4 | 2 | 5.04 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 92 | 0 | 8 | 3 | 5.02 | .325 | 1.41 | 7.9 | 4.8 | 10.4 | 95.0 | 83 | 58 | 53 | 8 | 51 | 110 | 0 | 8 | 1 | 0 | 0 | 3 | 3 | 3.48 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 75 | 0 | 4 | 2 | 4.67 | .288 | 1.16 | 8.1 | 2.4 | 9.1 | 79.0 | 71 | 47 | 41 | 15 | 21 | 80 | 0 | 11 | 2 | 0 | 0 | 4 | 0 | 4.39 |
| RP | Clase, E.Clase, Emmanuel >> | 26 | 2024 | R | 87 | 51 | 0 | 3 | 7 | 3.62 | .290 | 1.23 | 8.8 | 2.3 | 5.7 | 54.2 | 53 | 24 | 22 | 2 | 14 | 34 | 0 | 4 | 5 | 0 | 0 | 0 | 4 | 3.00 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 32 | 0 | 3 | 3 | 4.54 | .359 | 1.63 | 13.1 | 1.8 | 8.2 | 35.2 | 51 | 19 | 18 | 2 | 7 | 32 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 2.69 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 43 | 0 | 0 | 1 | 4.82 | .278 | 1.14 | 7.2 | 3.1 | 8.6 | 46.2 | 37 | 25 | 25 | 5 | 16 | 44 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.61 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 108 | 0 | 3 | 3 | 4.54 | .313 | 1.36 | 10.1 | 2.1 | 9.2 | 103.0 | 116 | 56 | 52 | 15 | 24 | 105 | 0 | 5 | 2 | 0 | 0 | 1 | 4 | 3.58 |