| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 84 | 21 | 21 | 4 | 8 | 4.99 | .328 | 1.43 | 9.5 | 3.5 | 9.5 | 122.2 | 129 | 73 | 68 | 19 | 47 | 129 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 4.16 |
| SP | Skenes, P.Skenes, Paul >> | 23 | 2025 | R | 73 | 20 | 20 | 3 | 7 | 5.48 | .339 | 1.50 | 10.6 | 2.9 | 10.4 | 113.1 | 133 | 71 | 69 | 14 | 37 | 130 | 0 | 0 | 0 | 0 | 4 | 4 | 1 | 3.40 |
| SP | Valdez, F.Valdez, Framber >> | 29 | 2023 | L | 15 | 20 | 20 | 6 | 11 | 5.17 | .323 | 1.43 | 9.3 | 3.7 | 8.3 | 123.2 | 127 | 72 | 71 | 21 | 50 | 114 | 1 | 0 | 0 | 0 | 9 | 0 | 6 | 4.59 |
| SP | Kelly, M.Kelly, Merrill >> | 34 | 2023 | R | 11 | 19 | 19 | 6 | 11 | 5.08 | .333 | 1.48 | 9.3 | 4.1 | 9.3 | 108.0 | 111 | 64 | 61 | 22 | 49 | 112 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 4.99 |
| SP | Takahashi, K.Takahashi, Kona >> | 24 | 2021 | R | 2 | 20 | 17 | 5 | 6 | 4.69 | .321 | 1.42 | 9.2 | 3.6 | 5.6 | 111.1 | 113 | 58 | 58 | 16 | 45 | 69 | 0 | 1 | 0 | 0 | 9 | 0 | 3 | 4.85 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 54 | 0 | 4 | 2 | 1.77 | .244 | 0.95 | 6.3 | 2.3 | 9.5 | 71.1 | 50 | 17 | 14 | 6 | 18 | 75 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 2.79 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 46 | 0 | 1 | 4 | 3.66 | .304 | 1.28 | 7.3 | 4.2 | 11.5 | 64.0 | 52 | 26 | 26 | 7 | 30 | 82 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 3.36 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 78 | 50 | 0 | 3 | 3 | 3.75 | .267 | 1.04 | 6.4 | 3.0 | 9.6 | 62.1 | 44 | 29 | 26 | 9 | 21 | 66 | 0 | 4 | 2 | 0 | 0 | 3 | 2 | 3.92 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 35 | 0 | 5 | 3 | 2.36 | .279 | 1.09 | 7.2 | 2.8 | 10.6 | 45.2 | 36 | 14 | 12 | 2 | 14 | 53 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 2.36 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 29 | 0 | 3 | 1 | 2.52 | .262 | 1.01 | 5.4 | 3.9 | 9.0 | 35.2 | 21 | 10 | 10 | 4 | 15 | 35 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.94 |
| RP | Cordero, F.Cordero, Francisco >> | 27 | 2002 | R | 21 | 23 | 0 | 0 | 1 | 6.39 | .372 | 1.78 | 13.0 | 3.2 | 10.4 | 25.1 | 36 | 18 | 18 | 6 | 9 | 29 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 4.88 |