| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 12 | 12 | 3 | 6 | 3.45 | .256 | 0.99 | 7.3 | 1.6 | 7.2 | 94.0 | 76 | 37 | 36 | 9 | 17 | 75 | 3 | 0 | 0 | 1 | 7 | 4 | 2 | 3.32 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 11 | 11 | 2 | 9 | 5.53 | .283 | 1.19 | 8.2 | 2.5 | 7.9 | 71.2 | 65 | 45 | 44 | 18 | 20 | 62 | 2 | 0 | 0 | 1 | 5 | 0 | 0 | 5.39 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 83 | 11 | 11 | 6 | 3 | 3.96 | .272 | 1.11 | 6.7 | 3.2 | 9.4 | 75.0 | 56 | 34 | 33 | 11 | 27 | 78 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 3.95 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 82 | 10 | 10 | 5 | 4 | 5.16 | .302 | 1.25 | 8.5 | 2.7 | 7.2 | 59.1 | 56 | 40 | 34 | 18 | 18 | 47 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 6.44 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 31 | 0 | 2 | 1 | 2.70 | .226 | 0.88 | 6.8 | 1.1 | 8.1 | 40.0 | 30 | 12 | 12 | 5 | 5 | 36 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.20 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 14 | 0 | 4 | 1 | 1.61 | .264 | 1.03 | 4.9 | 4.5 | 10.6 | 22.1 | 12 | 4 | 4 | 2 | 11 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.45 |
| RP | Clase, E.Clase, Emmanuel >> | 26 | 2024 | R | 87 | 14 | 0 | 1 | 0 | 2.63 | .241 | 0.88 | 7.6 | 0.7 | 3.5 | 13.2 | 11 | 4 | 4 | 2 | 1 | 5 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 4.69 |
| RP | Sutter, B.Sutter, Bruce >> | 28 | 1981 | R | 10 | 4 | 0 | 0 | 0 | 3.00 | .308 | 1.33 | 6.0 | 6.0 | 3.0 | 3.0 | 2 | 1 | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 3 | 0 | 0 | 0 | 12.46 | .381 | 1.85 | 11.3 | 6.8 | 18.0 | 4.1 | 5 | 6 | 6 | 0 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.25 |