| SP | Liriano, F.Liriano, Francisco $$ >> | 32 | 2006 | L | 100 | 32 | 32 | 12 | 12 | 4.16 | .292 | 1.23 | 8.5 | 2.6 | 9.7 | 201.0 | 190 | 99 | 93 | 34 | 58 | 216 | 2 | 0 | 0 | 0 | 19 | 1 | 9 | 3.93 |
| SP | Norris, B.Norris, Bud $$ >> | 30 | 2009 | R | 83 | 26 | 26 | 5 | 13 | 5.11 | .320 | 1.39 | 9.2 | 3.3 | 8.9 | 162.0 | 165 | 97 | 92 | 28 | 60 | 160 | 1 | 0 | 0 | 0 | 14 | 4 | 0 | 4.46 |
| SP | Litsch, J.Litsch, Jesse # $$ >> | 30 | 2007 | R | 83 | 33 | 33 | 6 | 18 | 4.77 | .313 | 1.36 | 10.0 | 2.3 | 6.0 | 213.1 | 237 | 123 | 113 | 33 | 54 | 142 | 2 | 0 | 0 | 0 | 17 | 1 | 3 | 4.46 |
| SP | Albers, A.Albers, Andrew $$ >> | 29 | 2013 | L | 77 | 33 | 33 | 7 | 20 | 5.14 | .323 | 1.42 | 10.5 | 2.3 | 5.7 | 213.2 | 249 | 131 | 122 | 42 | 55 | 136 | 0 | 0 | 0 | 0 | 15 | 2 | 0 | 5.09 |
| SP | Perkins, G.Perkins, Glen $ >> | 32 | 2008 | L | 56 | 31 | 31 | 10 | 16 | 4.32 | .293 | 1.24 | 8.7 | 2.5 | 5.8 | 216.2 | 209 | 109 | 104 | 29 | 60 | 139 | 0 | 0 | 0 | 0 | 17 | 1 | 1 | 4.31 |
| RP | Papelbon, J.Papelbon, Jonathan $$ >> | 34 | 2006 | R | 96 | 78 | 0 | 5 | 6 | 3.11 | .322 | 1.41 | 8.9 | 3.9 | 10.1 | 92.2 | 91 | 32 | 32 | 9 | 40 | 103 | 0 | 3 | 3 | 0 | 0 | 1 | 7 | 3.37 |
| RP | Ogando, A.Ogando, Alexi $$ >> | 31 | 2010 | R | 87 | 70 | 0 | 2 | 2 | 2.51 | .305 | 1.32 | 6.8 | 5.0 | 8.9 | 79.0 | 60 | 28 | 22 | 7 | 44 | 78 | 0 | 5 | 1 | 0 | 0 | 0 | 6 | 3.85 |
| CL | Chamberlain, J.Chamberlain, Joba $$ >> | 30 | 2008 | R | 85 | 65 | 0 | 8 | 6 | 3.57 | .299 | 1.26 | 8.5 | 2.9 | 9.5 | 75.2 | 71 | 30 | 30 | 4 | 24 | 79 | 0 | 24 | 3 | 0 | 0 | 2 | 1 | 2.63 |
| RP | Smith, J.Smith, Jordan $$ >> | 29 | 2010 | R | 77 | 47 | 0 | 1 | 2 | 4.81 | .336 | 1.50 | 11.8 | 1.7 | 6.5 | 58.0 | 76 | 31 | 31 | 10 | 11 | 42 | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 4.41 |
| RP | Lopez, W.Lopez, Wilton $$ >> | 31 | 2010 | R | 59 | 40 | 0 | 1 | 1 | 4.13 | .317 | 1.39 | 10.6 | 2.1 | 6.6 | 52.1 | 61 | 28 | 24 | 6 | 12 | 38 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.73 |
| RP | Eveland, D.Eveland, Dana $ >> | 32 | 2005 | L | 57 | 25 | 0 | 1 | 2 | 4.91 | .333 | 1.47 | 9.0 | 4.5 | 7.0 | 36.2 | 36 | 23 | 20 | 4 | 18 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.47 |
| SP | Duensing, B.Duensing, Brian $$ >> | 32 | 2009 | L | 42 | 19 | 14 | 4 | 7 | 4.36 | .313 | 1.37 | 8.4 | 3.9 | 6.3 | 95.0 | 89 | 51 | 46 | 13 | 41 | 67 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 4.66 |