| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 91 | 37 | 37 | 25 | 10 | 3.46 | .271 | 1.10 | 7.6 | 2.3 | 4.9 | 291.2 | 247 | 116 | 112 | 34 | 73 | 158 | 16 | 0 | 0 | 2 | 22 | 6 | 8 | 4.25 |
| SP | McQuillan, G.McQuillan, George >> | 22 | 1907 | R | 97 | 35 | 35 | 1 | 5 | 2.52 | .274 | 1.12 | 6.3 | 3.8 | 5.6 | 96.1 | 67 | 28 | 27 | 6 | 41 | 60 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 3.88 |
| SP | Wheeler, Z.Wheeler, Zack >> | 34 | 2024 | R | 82 | 34 | 34 | 20 | 7 | 4.24 | .292 | 1.21 | 8.2 | 2.7 | 8.4 | 229.1 | 209 | 115 | 108 | 36 | 69 | 215 | 4 | 0 | 0 | 2 | 16 | 6 | 7 | 4.15 |
| SP | Schilling, C.Schilling, Curt # >> | 29 | 1995 | R | 52 | 32 | 31 | 9 | 14 | 4.80 | .318 | 1.38 | 9.5 | 2.9 | 7.6 | 202.1 | 214 | 112 | 108 | 25 | 65 | 171 | 3 | 0 | 0 | 1 | 17 | 4 | 0 | 3.94 |
| SU | Strahm, M.Strahm, Matt >> | 32 | 2024 | L | 92 | 73 | 0 | 10 | 0 | 2.35 | .265 | 1.06 | 7.3 | 2.3 | 8.3 | 88.0 | 71 | 29 | 23 | 8 | 22 | 81 | 0 | 4 | 6 | 0 | 0 | 2 | 1 | 3.16 |
| RP | Valdes, R.Valdes, Raul † >> | 34 | 2012 | L | 90 | 83 | 0 | 20 | 2 | 1.89 | .255 | 1.03 | 7.4 | 1.9 | 10.2 | 90.1 | 74 | 21 | 19 | 5 | 19 | 102 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2.09 |
| RP | Wagner, B.Wagner, Billy >> | 33 | 2004 | L | 87 | 72 | 0 | 2 | 1 | 3.75 | .294 | 1.22 | 9.3 | 1.7 | 9.0 | 62.1 | 64 | 26 | 26 | 9 | 12 | 62 | 0 | 2 | 4 | 0 | 0 | 2 | 5 | 3.56 |
| RP | Bastardo, A.Bastardo, Antonio >> | 26 | 2011 | L | 81 | 52 | 0 | 5 | 1 | 2.01 | .253 | 0.97 | 5.0 | 3.8 | 7.7 | 40.1 | 22 | 10 | 9 | 3 | 17 | 34 | 0 | 0 | 1 | 0 | 0 | 2 | 5 | 3.70 |
| RP | Hoffman, J.Hoffman, Jeff >> | 30 | 2023 | R | 78 | 89 | 0 | 13 | 0 | 3.26 | .290 | 1.21 | 6.2 | 4.7 | 8.8 | 94.0 | 65 | 36 | 34 | 6 | 49 | 92 | 0 | 1 | 2 | 0 | 0 | 1 | 8 | 3.47 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 39 | 72 | 0 | 3 | 1 | 2.18 | .238 | 0.94 | 5.8 | 2.6 | 5.2 | 62.0 | 40 | 17 | 15 | 3 | 18 | 36 | 0 | 4 | 2 | 0 | 0 | 0 | 3 | 3.34 |
| RP | Urbina, U.Urbina, Ugueth >> | 31 | 2005 | R | 38 | 49 | 0 | 5 | 1 | 6.36 | .355 | 1.61 | 9.0 | 5.7 | 9.0 | 46.2 | 46 | 34 | 33 | 8 | 29 | 46 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.28 |