| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 29 | 29 | 15 | 11 | 2.35 | .248 | 0.97 | 5.8 | 3.0 | 7.5 | 225.2 | 144 | 63 | 59 | 16 | 74 | 187 | 11 | 0 | 0 | 6 | 21 | 5 | 2 | 3.32 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 95 | 28 | 28 | 16 | 8 | 2.95 | .266 | 1.07 | 5.2 | 4.4 | 8.4 | 195.1 | 113 | 67 | 64 | 11 | 96 | 183 | 5 | 0 | 0 | 4 | 20 | 3 | 4 | 3.38 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 67 | 28 | 28 | 14 | 5 | 3.53 | .303 | 1.27 | 7.0 | 4.4 | 8.2 | 173.1 | 135 | 69 | 68 | 11 | 85 | 158 | 0 | 0 | 0 | 0 | 16 | 6 | 3 | 3.58 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 54 | 28 | 28 | 11 | 7 | 4.13 | .315 | 1.36 | 7.9 | 4.4 | 9.0 | 180.2 | 158 | 86 | 83 | 25 | 87 | 179 | 0 | 0 | 0 | 0 | 15 | 4 | 6 | 4.33 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 72 | 24 | 0 | 2 | 1 | 3.27 | .298 | 1.27 | 9.0 | 2.5 | 6.5 | 22.0 | 22 | 8 | 8 | 3 | 6 | 16 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 23 | 0 | 1 | 1 | 4.03 | .293 | 1.17 | 5.6 | 5.0 | 9.9 | 29.0 | 18 | 13 | 13 | 3 | 16 | 32 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4.00 |