| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 15 | 15 | 6 | 3 | 4.25 | .279 | 1.11 | 7.0 | 3.0 | 8.8 | 101.2 | 79 | 50 | 48 | 15 | 34 | 99 | 0 | 0 | 0 | 0 | 7 | 5 | 0 | 4.13 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 84 | 15 | 15 | 8 | 2 | 2.92 | .263 | 1.07 | 6.8 | 2.9 | 7.9 | 101.2 | 76 | 35 | 33 | 9 | 33 | 89 | 1 | 0 | 0 | 1 | 10 | 0 | 2 | 3.38 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 67 | 15 | 15 | 6 | 7 | 3.80 | .308 | 1.33 | 7.5 | 4.5 | 8.5 | 92.1 | 77 | 45 | 39 | 12 | 46 | 87 | 1 | 0 | 0 | 1 | 10 | 0 | 2 | 4.30 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 56 | 15 | 15 | 7 | 5 | 4.52 | .308 | 1.31 | 7.0 | 4.9 | 9.9 | 93.2 | 72 | 49 | 47 | 13 | 51 | 102 | 1 | 0 | 0 | 0 | 9 | 2 | 3 | 4.33 |
| RP | Eckersley, D.Eckersley, Dennis # >> | 36 | 1990 | R | 86 | 41 | 0 | 4 | 3 | 3.98 | .256 | 1.01 | 7.3 | 1.8 | 10.2 | 54.1 | 44 | 24 | 24 | 10 | 11 | 61 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 36 | 0 | 2 | 4 | 2.23 | .262 | 1.04 | 7.7 | 1.8 | 8.1 | 40.1 | 34 | 10 | 10 | 6 | 8 | 36 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 25 | 0 | 0 | 3 | 6.35 | .352 | 1.59 | 9.0 | 5.7 | 11.0 | 22.2 | 22 | 16 | 16 | 4 | 14 | 27 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 4.95 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 15 | 0 | 0 | 1 | 2.53 | .273 | 1.13 | 5.4 | 5.4 | 7.2 | 10.2 | 6 | 3 | 3 | 2 | 6 | 8 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 5.80 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 7 | 0 | 0 | 0 | 9.00 | .423 | 2.20 | 16.2 | 3.6 | 12.6 | 5.0 | 9 | 5 | 5 | 2 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.60 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 60 | 8 | 0 | 1 | 0 | 9.49 | .397 | 1.95 | 14.4 | 3.3 | 7.2 | 30.1 | 48 | 32 | 32 | 11 | 11 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.37 |