| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 32 | 32 | 5 | 13 | 3.98 | .313 | 1.34 | 8.6 | 3.5 | 9.5 | 149.1 | 142 | 72 | 66 | 15 | 58 | 158 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 3.44 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 72 | 32 | 32 | 10 | 15 | 5.72 | .349 | 1.59 | 11.2 | 3.2 | 6.0 | 177.2 | 220 | 122 | 113 | 28 | 62 | 118 | 0 | 0 | 0 | 0 | 13 | 4 | 2 | 4.84 |
| RP | Uehara, K.Uehara, Koji # >> | 38 | 2013 | R | 100 | 82 | 0 | 10 | 5 | 4.67 | .280 | 1.16 | 8.2 | 2.2 | 9.8 | 117.2 | 107 | 61 | 61 | 18 | 29 | 127 | 0 | 6 | 4 | 0 | 0 | 1 | 2 | 3.60 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 80 | 0 | 7 | 6 | 3.61 | .275 | 1.12 | 7.6 | 2.5 | 9.4 | 112.1 | 95 | 49 | 45 | 18 | 31 | 117 | 0 | 9 | 2 | 0 | 0 | 2 | 0 | 3.88 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 94 | 72 | 0 | 7 | 3 | 4.98 | .320 | 1.38 | 8.3 | 4.1 | 11.0 | 85.0 | 78 | 49 | 47 | 17 | 39 | 104 | 0 | 3 | 1 | 0 | 0 | 3 | 3 | 4.64 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 62 | 0 | 1 | 4 | 3.77 | .279 | 1.16 | 5.3 | 5.2 | 10.3 | 71.2 | 42 | 32 | 30 | 9 | 41 | 81 | 0 | 10 | 2 | 0 | 0 | 0 | 13 | 4.10 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 51 | 0 | 3 | 1 | 3.88 | .335 | 1.51 | 10.5 | 3.3 | 10.3 | 55.2 | 64 | 28 | 24 | 5 | 20 | 63 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 2.98 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 54 | 45 | 0 | 1 | 1 | 5.57 | .305 | 1.32 | 8.1 | 3.9 | 10.2 | 51.2 | 46 | 36 | 32 | 7 | 22 | 58 | 0 | 1 | 0 | 0 | 0 | 0 | 6 | 3.80 |