| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 15 | 15 | 6 | 6 | 2.72 | .253 | 0.98 | 6.4 | 2.4 | 5.9 | 109.1 | 78 | 33 | 33 | 11 | 29 | 72 | 5 | 0 | 0 | 3 | 11 | 4 | 2 | 3.90 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 15 | 15 | 7 | 4 | 3.38 | .247 | 0.97 | 6.6 | 2.2 | 6.1 | 119.2 | 87 | 45 | 45 | 9 | 29 | 81 | 3 | 0 | 0 | 1 | 10 | 2 | 2 | 3.40 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 77 | 14 | 14 | 5 | 4 | 5.59 | .326 | 1.41 | 8.9 | 3.8 | 9.7 | 85.1 | 84 | 53 | 53 | 20 | 36 | 92 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 5.31 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 28 | 0 | 1 | 5 | 5.79 | .344 | 1.50 | 8.7 | 4.8 | 11.9 | 28.0 | 27 | 18 | 18 | 3 | 15 | 37 | 0 | 16 | 3 | 0 | 0 | 2 | 0 | 3.57 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 20 | 0 | 0 | 1 | 3.32 | .240 | 0.95 | 5.7 | 2.8 | 9.5 | 19.0 | 12 | 7 | 7 | 3 | 6 | 20 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 37 | 0 | 4 | 1 | 4.55 | .358 | 1.67 | 10.7 | 4.6 | 10.7 | 31.2 | 37 | 16 | 16 | 8 | 16 | 37 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.52 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 9 | 0 | 1 | 0 | 2.70 | .189 | 0.70 | 3.6 | 2.7 | 8.1 | 10.0 | 4 | 3 | 3 | 0 | 3 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.10 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 69 | 5 | 0 | 0 | 1 | 3.86 | .333 | 1.50 | 9.0 | 6.8 | 4.5 | 4.2 | 4 | 2 | 2 | 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.75 |