| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 6 | 9 | 2.95 | .262 | 1.05 | 7.3 | 2.1 | 9.9 | 207.1 | 168 | 71 | 68 | 24 | 49 | 227 | 0 | 0 | 0 | 0 | 21 | 4 | 0 | 3.08 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 29 | 29 | 6 | 13 | 4.44 | .302 | 1.26 | 8.5 | 2.8 | 8.4 | 178.1 | 168 | 91 | 88 | 34 | 56 | 166 | 2 | 0 | 0 | 1 | 15 | 8 | 9 | 4.70 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 75 | 28 | 28 | 9 | 14 | 6.17 | .352 | 1.58 | 11.0 | 3.3 | 9.5 | 156.0 | 190 | 114 | 107 | 27 | 57 | 164 | 1 | 0 | 0 | 0 | 10 | 7 | 1 | 4.38 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 28 | 28 | 9 | 9 | 4.22 | .316 | 1.36 | 9.1 | 3.2 | 6.2 | 170.2 | 171 | 81 | 80 | 25 | 61 | 118 | 1 | 0 | 0 | 0 | 17 | 5 | 2 | 4.69 |
| SP | Millwood, K.Millwood, Kevin # >> | 25 | 1999 | R | 69 | 27 | 27 | 5 | 17 | 5.23 | .296 | 1.23 | 8.4 | 2.7 | 6.6 | 173.2 | 161 | 102 | 101 | 40 | 52 | 127 | 1 | 0 | 0 | 0 | 10 | 6 | 2 | 5.54 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 75 | 0 | 5 | 5 | 3.80 | .304 | 1.29 | 7.5 | 4.2 | 8.4 | 106.2 | 88 | 47 | 45 | 9 | 50 | 99 | 0 | 8 | 2 | 0 | 0 | 2 | 5 | 3.71 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 72 | 0 | 4 | 8 | 5.01 | .334 | 1.49 | 9.3 | 4.3 | 10.5 | 91.2 | 94 | 56 | 51 | 15 | 43 | 106 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 4.26 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 63 | 0 | 4 | 5 | 2.64 | .252 | 1.00 | 7.7 | 1.3 | 9.0 | 78.1 | 67 | 24 | 23 | 9 | 11 | 78 | 0 | 7 | 5 | 0 | 0 | 1 | 0 | 2.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 36 | 0 | 2 | 2 | 3.91 | .300 | 1.24 | 9.8 | 1.5 | 8.8 | 48.1 | 52 | 21 | 21 | 8 | 8 | 47 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.83 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 30 | 0 | 3 | 0 | 2.25 | .255 | 1.03 | 6.5 | 2.8 | 10.5 | 36.0 | 26 | 9 | 9 | 6 | 11 | 42 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 58 | 7 | 0 | 4 | 2 | 0.84 | .347 | 1.50 | 9.0 | 5.4 | 4.5 | 10.2 | 10 | 3 | 1 | 1 | 6 | 5 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 5.40 |