| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 14 | 14 | 5 | 6 | 3.58 | .264 | 1.05 | 6.8 | 2.7 | 8.8 | 108.0 | 81 | 45 | 43 | 16 | 32 | 105 | 6 | 0 | 0 | 0 | 7 | 3 | 3 | 3.95 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 13 | 13 | 5 | 3 | 5.42 | .325 | 1.44 | 10.2 | 2.8 | 9.7 | 88.0 | 100 | 53 | 53 | 18 | 27 | 95 | 2 | 0 | 0 | 0 | 4 | 0 | 2 | 4.42 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 13 | 13 | 3 | 5 | 5.42 | .324 | 1.41 | 9.2 | 3.5 | 8.3 | 78.0 | 80 | 47 | 47 | 12 | 30 | 72 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.38 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 13 | 13 | 5 | 5 | 4.52 | .301 | 1.24 | 8.2 | 3.0 | 6.5 | 83.2 | 76 | 45 | 42 | 14 | 28 | 60 | 0 | 0 | 0 | 0 | 6 | 4 | 3 | 4.90 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 33 | 0 | 3 | 1 | 3.78 | .306 | 1.32 | 8.0 | 4.0 | 11.3 | 47.2 | 42 | 22 | 20 | 8 | 21 | 59 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 4.04 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 27 | 0 | 3 | 4 | 4.22 | .304 | 1.28 | 7.6 | 3.9 | 8.2 | 32.0 | 27 | 15 | 15 | 5 | 14 | 29 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.63 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 18 | 0 | 1 | 1 | 3.31 | .310 | 1.35 | 7.3 | 5.1 | 7.3 | 16.1 | 13 | 7 | 6 | 1 | 9 | 13 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.88 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 76 | 10 | 0 | 0 | 0 | 1.86 | .275 | 1.14 | 9.0 | 2.0 | 13.0 | 9.2 | 9 | 3 | 2 | 2 | 2 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.67 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 56 | 8 | 0 | 0 | 1 | 2.25 | .273 | 1.13 | 10.1 | 0.0 | 9.0 | 8.0 | 9 | 3 | 2 | 1 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.63 |