| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 29 | 29 | 14 | 12 | 4.15 | .307 | 1.30 | 9.0 | 2.7 | 8.8 | 204.0 | 204 | 97 | 94 | 25 | 62 | 200 | 3 | 0 | 0 | 1 | 18 | 5 | 3 | 3.62 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 87 | 28 | 28 | 10 | 11 | 4.86 | .314 | 1.34 | 9.6 | 2.4 | 9.2 | 181.1 | 194 | 103 | 98 | 28 | 49 | 185 | 1 | 0 | 0 | 1 | 13 | 6 | 8 | 3.88 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 27 | 27 | 14 | 5 | 3.51 | .271 | 1.11 | 7.7 | 2.4 | 5.8 | 153.2 | 131 | 64 | 60 | 16 | 40 | 98 | 0 | 0 | 0 | 0 | 10 | 0 | 0 | 3.86 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 28 | 28 | 8 | 14 | 4.56 | .315 | 1.36 | 9.0 | 3.3 | 5.7 | 185.1 | 184 | 103 | 94 | 27 | 68 | 118 | 4 | 0 | 0 | 0 | 15 | 4 | 5 | 4.79 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 31 | 28 | 13 | 10 | 4.62 | .314 | 1.35 | 9.1 | 3.1 | 8.9 | 165.2 | 166 | 86 | 85 | 27 | 57 | 164 | 0 | 0 | 0 | 0 | 18 | 4 | 4 | 4.25 |
| CL | Hochevar, L.Hochevar, Luke † >> | 30 | 2013 | R | 75 | 70 | 0 | 2 | 5 | 3.25 | .254 | 0.93 | 5.6 | 2.9 | 9.6 | 63.2 | 39 | 23 | 23 | 9 | 20 | 67 | 0 | 36 | 5 | 0 | 0 | 6 | 3 | 3.97 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 81 | 0 | 8 | 1 | 3.16 | .317 | 1.35 | 7.9 | 4.3 | 9.5 | 105.1 | 92 | 39 | 37 | 12 | 50 | 111 | 0 | 0 | 3 | 0 | 0 | 5 | 2 | 3.94 |
| RP | Soria, J.Soria, Joakim # >> | 24 | 2008 | R | 66 | 59 | 0 | 0 | 3 | 5.10 | .329 | 1.42 | 8.3 | 4.6 | 6.4 | 65.1 | 60 | 38 | 37 | 11 | 33 | 46 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 5.45 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 49 | 0 | 2 | 2 | 4.26 | .318 | 1.40 | 7.2 | 5.6 | 9.4 | 50.2 | 40 | 25 | 24 | 8 | 31 | 52 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.86 |