| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 23 | 23 | 15 | 2 | 2.95 | .281 | 1.17 | 8.3 | 2.3 | 7.1 | 176.2 | 162 | 59 | 58 | 22 | 45 | 138 | 2 | 0 | 0 | 1 | 16 | 0 | 1 | 3.82 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 22 | 22 | 14 | 2 | 2.25 | .255 | 1.03 | 6.6 | 2.7 | 5.0 | 151.2 | 110 | 38 | 38 | 10 | 46 | 84 | 1 | 0 | 0 | 1 | 14 | 0 | 3 | 3.66 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 5 | 9 | 4.55 | .300 | 1.27 | 9.0 | 2.5 | 7.4 | 150.1 | 150 | 79 | 76 | 20 | 41 | 124 | 1 | 0 | 0 | 0 | 13 | 2 | 5 | 3.94 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 22 | 22 | 10 | 6 | 4.34 | .302 | 1.25 | 8.9 | 2.4 | 4.2 | 155.2 | 153 | 80 | 75 | 17 | 42 | 72 | 4 | 0 | 0 | 0 | 11 | 7 | 2 | 4.45 |
| CL | Gallegos, G.Gallegos, Giovanny † # >> | 27 | 2019 | R | 82 | 50 | 0 | 2 | 6 | 4.02 | .319 | 1.40 | 8.2 | 4.4 | 7.1 | 47.0 | 43 | 21 | 21 | 4 | 23 | 37 | 0 | 33 | 5 | 0 | 0 | 0 | 1 | 4.00 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 61 | 0 | 2 | 1 | 2.23 | .262 | 1.04 | 6.1 | 3.4 | 9.2 | 40.1 | 27 | 10 | 10 | 3 | 15 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.13 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 39 | 0 | 3 | 3 | 2.28 | .303 | 1.27 | 7.7 | 4.0 | 10.0 | 27.2 | 23 | 7 | 7 | 2 | 12 | 30 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.19 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 24 | 0 | 3 | 1 | 5.21 | .367 | 1.74 | 11.4 | 4.3 | 5.2 | 19.0 | 24 | 11 | 11 | 3 | 9 | 11 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.32 |