| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 2 | 7 | 4.36 | .274 | 1.11 | 7.0 | 3.1 | 11.3 | 84.2 | 65 | 41 | 41 | 13 | 29 | 105 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 3.62 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 12 | 12 | 3 | 8 | 4.96 | .312 | 1.35 | 9.7 | 2.6 | 5.1 | 81.2 | 87 | 50 | 45 | 9 | 23 | 46 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 4.20 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 38 | 0 | 3 | 1 | 3.38 | .290 | 1.20 | 7.9 | 3.1 | 10.1 | 50.2 | 44 | 21 | 19 | 10 | 17 | 56 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.44 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 19 | 0 | 0 | 2 | 5.79 | .340 | 1.54 | 9.4 | 4.7 | 9.8 | 23.1 | 24 | 15 | 15 | 4 | 12 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.65 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 13 | 0 | 0 | 0 | 1.65 | .222 | 0.86 | 3.9 | 3.9 | 6.8 | 16.1 | 7 | 4 | 3 | 1 | 7 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.63 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 8 | 0 | 1 | 0 | 2.45 | .154 | 0.55 | 3.3 | 1.6 | 8.2 | 11.0 | 4 | 5 | 3 | 1 | 2 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 61 | 8 | 0 | 0 | 0 | 19.89 | .513 | 3.16 | 24.0 | 6.0 | 9.0 | 6.1 | 16 | 17 | 14 | 8 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 20.33 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 0 | 0 | 0 | 18.00 | .625 | 5.00 | 18.0 | 27.0 | 0.0 | 1.0 | 2 | 2 | 2 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12.00 |