| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 13 | 13 | 5 | 5 | 4.47 | .292 | 1.20 | 8.2 | 2.7 | 5.3 | 90.2 | 82 | 45 | 45 | 17 | 27 | 53 | 2 | 0 | 0 | 1 | 7 | 3 | 1 | 5.28 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 13 | 13 | 7 | 3 | 3.46 | .315 | 1.37 | 10.1 | 2.3 | 5.3 | 96.1 | 108 | 42 | 37 | 6 | 24 | 56 | 4 | 0 | 0 | 0 | 8 | 1 | 2 | 3.43 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 13 | 12 | 4 | 4 | 5.47 | .368 | 1.68 | 10.0 | 5.1 | 5.7 | 74.0 | 82 | 46 | 45 | 10 | 42 | 47 | 1 | 0 | 0 | 1 | 4 | 5 | 3 | 5.39 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 31 | 0 | 4 | 0 | 4.50 | .321 | 1.42 | 8.8 | 4.0 | 11.1 | 38.0 | 37 | 19 | 19 | 5 | 17 | 47 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 26 | 0 | 1 | 1 | 4.18 | .326 | 1.42 | 9.6 | 3.4 | 9.0 | 32.1 | 34 | 17 | 15 | 4 | 12 | 32 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 26 | 0 | 0 | 3 | 4.30 | .273 | 1.13 | 8.4 | 1.9 | 9.9 | 29.1 | 27 | 14 | 14 | 7 | 6 | 32 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4.55 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 16 | 0 | 1 | 1 | 4.34 | .356 | 1.66 | 11.5 | 4.0 | 8.5 | 18.2 | 23 | 9 | 9 | 4 | 8 | 17 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.33 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 14 | 0 | 0 | 0 | 2.30 | .309 | 1.34 | 7.8 | 4.8 | 4.2 | 15.2 | 13 | 5 | 4 | 3 | 8 | 7 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 6.27 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 3 | 0 | 0 | 2 | 8.44 | .467 | 2.63 | 18.0 | 7.2 | 3.6 | 5.1 | 10 | 5 | 5 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.20 |