| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 36 | 36 | 16 | 13 | 3.72 | .301 | 1.29 | 8.5 | 3.1 | 5.1 | 263.2 | 248 | 132 | 109 | 17 | 91 | 150 | 4 | 0 | 0 | 1 | 23 | 1 | 5 | 3.75 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 35 | 35 | 16 | 9 | 4.59 | .335 | 1.50 | 7.9 | 5.6 | 4.2 | 221.1 | 194 | 128 | 113 | 19 | 137 | 103 | 0 | 0 | 0 | 0 | 17 | 3 | 2 | 5.09 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 33 | 33 | 16 | 11 | 4.39 | .334 | 1.49 | 8.2 | 5.2 | 7.9 | 211.0 | 192 | 112 | 103 | 21 | 122 | 186 | 0 | 0 | 0 | 0 | 20 | 4 | 5 | 4.32 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 33 | 32 | 13 | 10 | 4.44 | .335 | 1.47 | 8.1 | 5.2 | 4.3 | 214.2 | 193 | 126 | 106 | 23 | 123 | 102 | 2 | 0 | 0 | 0 | 16 | 8 | 3 | 5.28 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 23 | 20 | 1 | 3 | 4.76 | .340 | 1.50 | 8.7 | 4.9 | 9.7 | 92.2 | 89 | 55 | 49 | 13 | 50 | 99 | 0 | 0 | 0 | 0 | 0 | 4 | 6 | 4.45 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 99 | 0 | 6 | 2 | 3.92 | .276 | 1.15 | 9.2 | 1.1 | 7.2 | 80.1 | 82 | 40 | 35 | 9 | 10 | 64 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.24 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 100 | 0 | 5 | 3 | 2.77 | .270 | 1.08 | 6.9 | 2.9 | 9.0 | 74.2 | 57 | 26 | 23 | 4 | 24 | 74 | 0 | 2 | 3 | 0 | 0 | 2 | 5 | 2.76 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 69 | 0 | 1 | 0 | 3.89 | .302 | 1.30 | 8.8 | 2.9 | 8.5 | 37.0 | 36 | 18 | 16 | 4 | 12 | 35 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.49 |
| CL | Williams, D.Williams, Devin † >> | 28 | 2023 | R | 73 | 63 | 0 | 1 | 7 | 3.56 | .300 | 1.25 | 6.3 | 5.1 | 9.3 | 60.2 | 42 | 27 | 24 | 5 | 34 | 62 | 0 | 40 | 7 | 0 | 0 | 2 | 1 | 3.82 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 61 | 71 | 0 | 6 | 3 | 4.43 | .302 | 1.28 | 8.6 | 3.0 | 7.1 | 61.0 | 58 | 34 | 30 | 11 | 20 | 48 | 0 | 5 | 4 | 0 | 0 | 1 | 2 | 4.80 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 45 | 0 | 4 | 3 | 2.93 | .277 | 1.13 | 7.4 | 2.7 | 8.3 | 40.0 | 33 | 16 | 13 | 7 | 12 | 37 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.40 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 39 | 0 | 4 | 1 | 3.69 | .302 | 1.29 | 7.8 | 3.9 | 7.8 | 46.1 | 40 | 23 | 19 | 4 | 20 | 40 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.70 |
| SP | Tanana, F.Tanana, Frank # >> | 23 | 1976 | L | 57 | 20 | 8 | 3 | 8 | 6.15 | .346 | 1.56 | 10.2 | 3.9 | 6.5 | 90.2 | 102 | 71 | 62 | 18 | 39 | 65 | 3 | 1 | 0 | 0 | 1 | 3 | 3 | 5.56 |