| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 23 | 23 | 2 | 10 | 4.83 | .309 | 1.32 | 9.0 | 2.9 | 5.8 | 147.1 | 147 | 81 | 79 | 15 | 48 | 94 | 4 | 0 | 0 | 0 | 10 | 3 | 0 | 4.09 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 22 | 22 | 5 | 10 | 4.93 | .336 | 1.50 | 9.7 | 3.9 | 8.6 | 127.2 | 137 | 71 | 70 | 15 | 55 | 122 | 0 | 0 | 0 | 0 | 12 | 2 | 5 | 3.96 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 20 | 20 | 2 | 12 | 8.53 | .395 | 1.94 | 14.0 | 3.6 | 5.8 | 88.2 | 137 | 102 | 84 | 27 | 35 | 57 | 1 | 0 | 0 | 0 | 2 | 2 | 3 | 6.95 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 20 | 4 | 9 | 5.47 | .345 | 1.56 | 10.3 | 3.9 | 5.7 | 121.2 | 138 | 88 | 74 | 23 | 52 | 77 | 2 | 0 | 0 | 0 | 8 | 2 | 2 | 5.54 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 72 | 0 | 5 | 3 | 4.30 | .322 | 1.39 | 9.7 | 2.9 | 10.1 | 83.2 | 89 | 43 | 40 | 13 | 27 | 93 | 0 | 3 | 4 | 0 | 0 | 3 | 2 | 3.88 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 61 | 0 | 4 | 6 | 4.70 | .300 | 1.28 | 9.4 | 2.1 | 8.2 | 88.0 | 92 | 48 | 46 | 10 | 21 | 80 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 51 | 0 | 5 | 3 | 6.22 | .348 | 1.60 | 8.7 | 5.9 | 8.6 | 63.2 | 61 | 46 | 44 | 7 | 41 | 60 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 4.49 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 48 | 0 | 6 | 3 | 4.03 | .320 | 1.41 | 9.5 | 3.3 | 6.2 | 58.0 | 61 | 26 | 26 | 10 | 21 | 40 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 4.95 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 37 | 0 | 2 | 0 | 5.17 | .299 | 1.26 | 6.9 | 4.4 | 6.3 | 47.0 | 36 | 30 | 27 | 6 | 23 | 33 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 4.79 |