| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 20 | 20 | 7 | 10 | 4.75 | .318 | 1.37 | 10.0 | 2.5 | 5.2 | 113.2 | 125 | 63 | 60 | 21 | 31 | 65 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 5.17 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 21 | 21 | 8 | 5 | 3.70 | .290 | 1.22 | 8.7 | 2.3 | 5.4 | 121.2 | 117 | 58 | 50 | 16 | 31 | 73 | 3 | 0 | 0 | 1 | 15 | 1 | 2 | 4.31 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 21 | 20 | 8 | 5 | 4.09 | .311 | 1.35 | 9.8 | 2.4 | 4.8 | 127.2 | 138 | 62 | 58 | 15 | 34 | 68 | 2 | 0 | 0 | 0 | 13 | 1 | 3 | 4.29 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 53 | 0 | 5 | 7 | 3.45 | .289 | 1.15 | 7.1 | 3.3 | 9.6 | 57.1 | 45 | 30 | 22 | 4 | 21 | 61 | 0 | 19 | 4 | 0 | 0 | 4 | 1 | 3.09 |
| SU | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 53 | 0 | 1 | 3 | 4.15 | .338 | 1.52 | 9.2 | 4.7 | 8.6 | 60.2 | 61 | 30 | 28 | 8 | 31 | 57 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 4.43 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 67 | 0 | 1 | 2 | 4.19 | .335 | 1.51 | 8.4 | 5.3 | 9.4 | 77.1 | 72 | 42 | 36 | 14 | 45 | 80 | 0 | 6 | 3 | 0 | 0 | 0 | 2 | 5.04 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 51 | 0 | 3 | 3 | 4.82 | .302 | 1.30 | 9.6 | 2.2 | 8.0 | 65.1 | 69 | 37 | 35 | 10 | 16 | 58 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 43 | 0 | 2 | 2 | 4.67 | .342 | 1.56 | 9.7 | 4.3 | 8.0 | 52.0 | 56 | 29 | 27 | 6 | 25 | 46 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.17 |