| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 36 | 36 | 16 | 11 | 3.85 | .288 | 1.19 | 7.8 | 3.0 | 8.1 | 219.2 | 189 | 99 | 94 | 25 | 73 | 196 | 1 | 0 | 0 | 0 | 21 | 5 | 4 | 3.76 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 35 | 35 | 8 | 15 | 4.68 | .329 | 1.46 | 9.8 | 3.4 | 5.2 | 205.2 | 223 | 115 | 107 | 27 | 77 | 119 | 3 | 0 | 0 | 1 | 14 | 3 | 2 | 4.72 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 34 | 33 | 13 | 8 | 4.32 | .310 | 1.34 | 7.8 | 4.3 | 5.6 | 191.2 | 165 | 95 | 92 | 18 | 91 | 118 | 1 | 0 | 0 | 0 | 19 | 2 | 2 | 4.45 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 35 | 31 | 14 | 9 | 3.61 | .301 | 1.27 | 9.3 | 2.2 | 4.3 | 207.0 | 213 | 93 | 83 | 19 | 50 | 99 | 3 | 0 | 0 | 1 | 18 | 4 | 3 | 4.02 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 95 | 0 | 9 | 1 | 3.71 | .293 | 1.23 | 7.4 | 3.7 | 8.0 | 111.2 | 91 | 46 | 46 | 12 | 46 | 99 | 0 | 1 | 1 | 0 | 0 | 2 | 11 | 3.92 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 77 | 0 | 4 | 8 | 6.01 | .319 | 1.38 | 9.1 | 3.4 | 9.2 | 85.1 | 86 | 59 | 57 | 13 | 32 | 87 | 0 | 3 | 1 | 0 | 0 | 2 | 4 | 4.14 |
| CL | Hoffman, T.Hoffman, Trevor † >> | 31 | 1998 | R | 75 | 87 | 0 | 3 | 8 | 4.19 | .323 | 1.43 | 7.3 | 5.6 | 8.8 | 92.1 | 75 | 44 | 43 | 8 | 57 | 90 | 0 | 42 | 3 | 0 | 0 | 0 | 5 | 4.03 |
| SU | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 79 | 0 | 0 | 6 | 4.39 | .288 | 1.21 | 7.4 | 3.6 | 10.0 | 96.1 | 79 | 48 | 47 | 12 | 38 | 107 | 0 | 3 | 10 | 0 | 0 | 0 | 3 | 3.58 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 72 | 0 | 7 | 0 | 4.55 | .337 | 1.51 | 9.0 | 4.6 | 5.8 | 89.0 | 89 | 51 | 45 | 8 | 45 | 57 | 0 | 0 | 2 | 0 | 0 | 2 | 7 | 4.47 |