| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 37 | 37 | 13 | 15 | 4.85 | .306 | 1.29 | 8.8 | 2.9 | 9.0 | 221.0 | 216 | 125 | 119 | 32 | 70 | 221 | 0 | 0 | 0 | 0 | 21 | 7 | 0 | 3.93 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 36 | 36 | 14 | 15 | 4.91 | .323 | 1.42 | 10.4 | 2.4 | 5.4 | 240.0 | 277 | 152 | 131 | 38 | 63 | 143 | 4 | 0 | 0 | 0 | 14 | 4 | 4 | 4.70 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 34 | 34 | 15 | 13 | 4.58 | .308 | 1.33 | 9.8 | 2.2 | 8.6 | 229.2 | 249 | 123 | 117 | 29 | 56 | 220 | 4 | 0 | 0 | 1 | 16 | 2 | 3 | 3.48 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 84 | 0 | 5 | 4 | 5.62 | .352 | 1.59 | 9.6 | 4.7 | 8.1 | 99.1 | 106 | 65 | 62 | 7 | 52 | 89 | 0 | 11 | 5 | 0 | 0 | 4 | 4 | 3.82 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 67 | 0 | 4 | 3 | 5.44 | .326 | 1.45 | 9.9 | 3.3 | 9.2 | 82.2 | 90 | 57 | 50 | 11 | 30 | 84 | 0 | 11 | 2 | 0 | 0 | 0 | 3 | 3.79 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 50 | 0 | 3 | 2 | 2.64 | .295 | 1.26 | 7.5 | 3.8 | 8.0 | 61.1 | 51 | 25 | 18 | 8 | 26 | 54 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 4.21 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 41 | 0 | 3 | 2 | 4.31 | .333 | 1.42 | 8.1 | 4.7 | 8.4 | 48.0 | 43 | 30 | 23 | 5 | 25 | 45 | 0 | 1 | 0 | 0 | 0 | 4 | 5 | 4.29 |