| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 17 | 17 | 5 | 10 | 5.57 | .310 | 1.32 | 9.7 | 2.3 | 8.9 | 119.2 | 128 | 75 | 74 | 26 | 30 | 118 | 4 | 0 | 0 | 0 | 7 | 3 | 4 | 4.69 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 16 | 16 | 3 | 11 | 6.24 | .366 | 1.71 | 10.3 | 5.1 | 7.3 | 98.0 | 112 | 70 | 68 | 13 | 56 | 79 | 1 | 0 | 0 | 0 | 5 | 2 | 3 | 4.89 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 16 | 16 | 3 | 9 | 6.25 | .345 | 1.56 | 10.8 | 3.3 | 7.2 | 99.1 | 119 | 71 | 69 | 14 | 36 | 79 | 1 | 0 | 0 | 1 | 6 | 2 | 6 | 4.39 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2007 | R | 48 | 16 | 16 | 6 | 8 | 5.22 | .306 | 1.31 | 9.7 | 2.0 | 9.6 | 110.1 | 119 | 65 | 64 | 17 | 25 | 117 | 2 | 0 | 0 | 1 | 6 | 2 | 1 | 3.62 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 42 | 0 | 2 | 4 | 5.11 | .310 | 1.33 | 9.4 | 2.7 | 8.6 | 61.2 | 64 | 36 | 35 | 9 | 18 | 58 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.95 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 37 | 0 | 2 | 1 | 3.77 | .321 | 1.42 | 6.9 | 5.9 | 10.5 | 43.0 | 33 | 21 | 18 | 4 | 28 | 50 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.84 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 47 | 24 | 0 | 0 | 0 | 4.50 | .343 | 1.57 | 9.9 | 4.2 | 4.8 | 30.0 | 33 | 17 | 15 | 2 | 14 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.20 |
| RP | Aardsma, D.Aardsma, David >> | 28 | 2009 | R | 38 | 25 | 0 | 0 | 0 | 2.42 | .302 | 1.25 | 7.0 | 4.5 | 10.6 | 22.1 | 17 | 8 | 6 | 2 | 11 | 26 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.45 |
| RP | Stewart, S.Stewart, Scott >> | 27 | 2002 | L | 29 | 20 | 0 | 0 | 2 | 5.74 | .322 | 1.39 | 9.0 | 3.8 | 9.0 | 26.2 | 26 | 18 | 17 | 5 | 11 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.88 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 47 | 1 | 0 | 0 | 1 | 5.06 | .467 | 2.44 | 18.0 | 5.4 | 9.0 | 5.1 | 10 | 3 | 3 | 1 | 3 | 5 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 6.00 |