| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 25 | 25 | 5 | 12 | 3.25 | .296 | 1.24 | 8.0 | 3.2 | 9.8 | 119.0 | 106 | 45 | 43 | 12 | 42 | 129 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 3.25 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 24 | 24 | 9 | 8 | 4.31 | .319 | 1.39 | 10.3 | 2.3 | 8.4 | 144.0 | 164 | 77 | 69 | 20 | 36 | 135 | 3 | 0 | 0 | 0 | 13 | 2 | 1 | 3.72 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 23 | 23 | 3 | 10 | 4.96 | .358 | 1.64 | 11.2 | 3.7 | 6.1 | 101.2 | 126 | 62 | 56 | 14 | 41 | 69 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 4.74 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 23 | 23 | 9 | 8 | 5.21 | .317 | 1.31 | 8.6 | 3.3 | 6.6 | 141.2 | 134 | 85 | 82 | 33 | 52 | 104 | 6 | 0 | 0 | 2 | 9 | 11 | 0 | 5.91 |
| CL | Gagne, E.Gagne, Eric † $ >> | 27 | 2003 | R | 100 | 47 | 0 | 5 | 2 | 1.48 | .240 | 0.92 | 5.4 | 3.0 | 11.8 | 48.2 | 29 | 8 | 8 | 2 | 16 | 63 | 0 | 22 | 4 | 0 | 0 | 1 | 0 | 1.98 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 53 | 0 | 4 | 0 | 2.60 | .255 | 1.01 | 7.0 | 2.2 | 7.4 | 62.1 | 48 | 20 | 18 | 10 | 15 | 51 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 4.23 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 58 | 0 | 4 | 2 | 3.13 | .296 | 1.22 | 6.3 | 4.7 | 11.6 | 74.2 | 52 | 29 | 26 | 9 | 39 | 95 | 0 | 1 | 2 | 0 | 0 | 3 | 3 | 3.72 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 51 | 0 | 6 | 2 | 2.69 | .251 | 0.96 | 6.3 | 2.4 | 8.7 | 83.2 | 58 | 25 | 25 | 8 | 22 | 80 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 3.27 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 44 | 0 | 4 | 2 | 3.78 | .323 | 1.39 | 8.1 | 4.5 | 9.2 | 52.1 | 47 | 23 | 22 | 6 | 26 | 53 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.08 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 40 | 0 | 5 | 1 | 2.72 | .284 | 1.17 | 8.6 | 2.0 | 5.9 | 49.2 | 47 | 19 | 15 | 4 | 11 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.49 |