| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 28 | 28 | 8 | 11 | 4.35 | .286 | 1.17 | 8.0 | 2.7 | 9.9 | 173.2 | 153 | 88 | 84 | 23 | 51 | 191 | 0 | 0 | 0 | 0 | 15 | 5 | 0 | 3.49 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 27 | 27 | 14 | 5 | 3.83 | .291 | 1.21 | 8.0 | 2.8 | 5.5 | 188.0 | 168 | 86 | 80 | 19 | 59 | 114 | 8 | 0 | 0 | 3 | 16 | 4 | 8 | 4.11 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 26 | 26 | 5 | 17 | 5.43 | .327 | 1.43 | 9.8 | 3.2 | 5.3 | 175.2 | 190 | 112 | 106 | 29 | 62 | 104 | 8 | 0 | 0 | 0 | 9 | 4 | 1 | 5.10 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 27 | 27 | 6 | 12 | 6.28 | .341 | 1.53 | 11.3 | 2.4 | 5.2 | 173.1 | 218 | 125 | 121 | 33 | 47 | 100 | 8 | 0 | 0 | 1 | 7 | 4 | 2 | 5.21 |
| RP | Adams, M.Adams, Mike # >> | 31 | 2009 | R | 99 | 65 | 0 | 5 | 4 | 4.83 | .330 | 1.44 | 8.8 | 4.3 | 7.5 | 76.1 | 74 | 42 | 41 | 10 | 36 | 63 | 0 | 3 | 3 | 0 | 0 | 3 | 4 | 4.59 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 58 | 0 | 5 | 4 | 4.33 | .318 | 1.40 | 7.3 | 5.4 | 8.4 | 62.1 | 50 | 32 | 30 | 6 | 37 | 58 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 45 | 0 | 2 | 3 | 1.82 | .262 | 1.07 | 5.7 | 4.0 | 9.7 | 54.1 | 34 | 13 | 11 | 3 | 24 | 58 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 32 | 0 | 3 | 1 | 3.00 | .250 | 0.95 | 6.4 | 2.1 | 6.4 | 42.0 | 30 | 15 | 14 | 4 | 10 | 30 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 3.67 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 27 | 0 | 1 | 2 | 7.16 | .376 | 1.77 | 11.0 | 5.3 | 8.3 | 27.2 | 33 | 23 | 22 | 5 | 16 | 25 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 5.44 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 23 | 0 | 1 | 1 | 2.96 | .299 | 1.21 | 7.3 | 3.7 | 8.0 | 27.1 | 22 | 12 | 9 | 1 | 11 | 24 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.15 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 9 | 2 | 2 | 2 | 4.55 | .325 | 1.41 | 11.0 | 2.0 | 5.0 | 27.2 | 33 | 16 | 14 | 6 | 6 | 15 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 5.56 |