| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 28 | 28 | 10 | 8 | 3.66 | .260 | 1.04 | 7.7 | 1.6 | 8.7 | 213.2 | 183 | 90 | 87 | 36 | 39 | 205 | 4 | 0 | 0 | 1 | 15 | 3 | 7 | 3.86 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 27 | 27 | 7 | 14 | 5.42 | .331 | 1.46 | 10.7 | 2.5 | 7.8 | 174.1 | 206 | 109 | 105 | 28 | 48 | 150 | 3 | 0 | 0 | 1 | 12 | 5 | 7 | 4.28 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 26 | 26 | 11 | 9 | 3.58 | .257 | 1.04 | 7.6 | 1.7 | 4.8 | 193.2 | 164 | 85 | 77 | 20 | 37 | 104 | 5 | 0 | 0 | 3 | 15 | 0 | 3 | 3.84 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 70 | 0 | 7 | 5 | 3.84 | .307 | 1.32 | 7.6 | 4.3 | 6.9 | 84.1 | 71 | 40 | 36 | 14 | 40 | 64 | 0 | 10 | 3 | 0 | 0 | 1 | 5 | 5.11 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 39 | 0 | 2 | 6 | 6.43 | .357 | 1.64 | 9.6 | 5.1 | 9.0 | 42.0 | 45 | 30 | 30 | 15 | 24 | 42 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 7.43 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 19 | 0 | 0 | 0 | 3.96 | .279 | 1.16 | 7.2 | 3.2 | 7.2 | 25.0 | 20 | 11 | 11 | 3 | 9 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.04 |