| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 14 | 13 | 3.94 | .285 | 1.18 | 9.0 | 1.7 | 7.8 | 244.2 | 243 | 119 | 107 | 38 | 45 | 212 | 10 | 0 | 0 | 1 | 20 | 4 | 7 | 3.89 |
| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 92 | 32 | 32 | 13 | 11 | 3.51 | .302 | 1.28 | 8.3 | 3.2 | 7.5 | 220.2 | 204 | 101 | 86 | 21 | 78 | 184 | 6 | 0 | 0 | 0 | 22 | 4 | 3 | 3.69 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 31 | 7 | 17 | 6.12 | .344 | 1.53 | 9.9 | 3.9 | 4.6 | 185.1 | 204 | 137 | 126 | 37 | 80 | 94 | 5 | 0 | 0 | 1 | 9 | 8 | 1 | 6.01 |
| RP | Papelbon, J.Papelbon, Jonathan # >> | 27 | 2007 | R | 92 | 59 | 0 | 5 | 6 | 5.80 | .337 | 1.49 | 7.6 | 5.8 | 9.8 | 59.0 | 50 | 39 | 38 | 5 | 38 | 64 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 3.97 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 39 | 0 | 2 | 3 | 4.44 | .270 | 1.09 | 7.7 | 2.3 | 8.3 | 48.2 | 41 | 24 | 24 | 7 | 12 | 44 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 3.88 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 24 | 0 | 0 | 2 | 6.93 | .357 | 1.62 | 11.3 | 3.8 | 10.9 | 24.2 | 30 | 19 | 19 | 7 | 10 | 29 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.75 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 8 | 0 | 0 | 1 | 6.39 | .377 | 1.82 | 13.5 | 3.8 | 5.3 | 12.2 | 18 | 10 | 9 | 3 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 6.33 |