| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 27 | 27 | 11 | 8 | 3.68 | .287 | 1.20 | 7.7 | 3.1 | 7.8 | 200.2 | 172 | 83 | 82 | 21 | 68 | 173 | 11 | 0 | 0 | 5 | 12 | 2 | 4 | 3.69 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 24 | 24 | 5 | 9 | 4.43 | .315 | 1.36 | 10.2 | 2.1 | 4.7 | 160.2 | 182 | 84 | 79 | 16 | 37 | 84 | 4 | 0 | 0 | 1 | 14 | 3 | 2 | 4.00 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 26 | 26 | 15 | 6 | 3.14 | .273 | 1.12 | 7.4 | 2.8 | 5.1 | 206.2 | 169 | 74 | 72 | 19 | 63 | 117 | 12 | 0 | 0 | 5 | 15 | 1 | 1 | 4.00 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 26 | 26 | 9 | 15 | 5.54 | .323 | 1.42 | 10.1 | 2.7 | 4.4 | 167.1 | 188 | 109 | 103 | 23 | 50 | 81 | 10 | 0 | 0 | 2 | 9 | 1 | 5 | 4.74 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 26 | 26 | 7 | 13 | 6.48 | .332 | 1.47 | 9.3 | 4.0 | 5.5 | 157.0 | 162 | 116 | 113 | 22 | 69 | 96 | 2 | 0 | 0 | 1 | 7 | 3 | 0 | 4.97 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 62 | 0 | 3 | 6 | 4.37 | .296 | 1.26 | 9.0 | 2.4 | 8.5 | 82.1 | 82 | 41 | 40 | 12 | 22 | 77 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 3.83 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 49 | 0 | 4 | 3 | 4.45 | .298 | 1.25 | 8.2 | 3.2 | 8.5 | 56.2 | 51 | 38 | 28 | 12 | 20 | 53 | 0 | 8 | 5 | 0 | 0 | 1 | 2 | 5.02 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 40 | 0 | 4 | 4 | 5.62 | .335 | 1.51 | 10.8 | 2.9 | 9.7 | 49.2 | 59 | 31 | 31 | 7 | 16 | 53 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 3.67 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 25 | 0 | 2 | 0 | 2.64 | .270 | 1.11 | 5.7 | 4.5 | 6.6 | 30.2 | 19 | 9 | 9 | 3 | 15 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 4.33 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 26 | 0 | 2 | 1 | 2.36 | .285 | 1.17 | 8.5 | 2.1 | 6.4 | 34.1 | 32 | 9 | 9 | 2 | 8 | 24 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.15 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 16 | 2 | 1 | 3 | 7.58 | .369 | 1.75 | 13.0 | 3.1 | 6.5 | 29.2 | 42 | 31 | 25 | 8 | 10 | 21 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 6.17 |