| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 27 | 27 | 13 | 8 | 3.35 | .291 | 1.21 | 8.2 | 2.7 | 7.6 | 193.1 | 176 | 75 | 72 | 21 | 58 | 163 | 2 | 0 | 0 | 2 | 19 | 4 | 1 | 3.69 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 26 | 26 | 10 | 12 | 5.06 | .303 | 1.29 | 7.4 | 4.2 | 4.0 | 176.0 | 145 | 102 | 99 | 15 | 82 | 78 | 5 | 0 | 0 | 0 | 11 | 3 | 4 | 4.67 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 72 | 0 | 4 | 2 | 3.17 | .272 | 1.12 | 7.8 | 2.3 | 7.9 | 93.2 | 81 | 37 | 33 | 9 | 24 | 82 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 3.27 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 57 | 0 | 5 | 2 | 2.92 | .247 | 0.99 | 7.6 | 1.3 | 8.6 | 71.0 | 60 | 26 | 23 | 10 | 10 | 68 | 0 | 10 | 4 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 43 | 0 | 1 | 3 | 3.28 | .308 | 1.30 | 8.3 | 3.5 | 7.9 | 49.1 | 45 | 19 | 18 | 5 | 19 | 43 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 3.86 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 27 | 0 | 2 | 5 | 5.34 | .368 | 1.71 | 9.6 | 6.0 | 7.8 | 30.1 | 32 | 19 | 18 | 4 | 20 | 26 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 5.10 |
| RP | Messersmith, A.Messersmith, Andy # >> | 23 | 1968 | R | 58 | 23 | 0 | 0 | 0 | 4.24 | .331 | 1.46 | 7.2 | 6.1 | 7.7 | 40.1 | 32 | 20 | 19 | 5 | 27 | 34 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.03 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 5 | 0 | 0 | 1 | 1.80 | .318 | 1.40 | 5.4 | 7.2 | 9.0 | 5.0 | 3 | 1 | 1 | 1 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.00 |