| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 33 | 33 | 11 | 11 | 3.76 | .284 | 1.15 | 8.2 | 2.2 | 6.0 | 227.2 | 207 | 99 | 95 | 19 | 55 | 152 | 6 | 0 | 0 | 2 | 21 | 9 | 1 | 3.59 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 31 | 31 | 9 | 12 | 4.76 | .338 | 1.49 | 8.6 | 4.9 | 8.4 | 181.1 | 173 | 101 | 96 | 15 | 98 | 168 | 0 | 0 | 0 | 0 | 12 | 7 | 4 | 3.96 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 32 | 32 | 14 | 12 | 3.84 | .297 | 1.24 | 8.2 | 2.9 | 8.9 | 211.0 | 193 | 90 | 90 | 26 | 69 | 208 | 4 | 0 | 0 | 1 | 18 | 6 | 7 | 3.70 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 32 | 32 | 11 | 12 | 5.72 | .338 | 1.49 | 10.4 | 3.1 | 5.8 | 190.1 | 219 | 128 | 121 | 35 | 65 | 123 | 7 | 0 | 0 | 1 | 10 | 7 | 1 | 5.24 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 31 | 31 | 12 | 14 | 4.87 | .334 | 1.48 | 10.2 | 3.2 | 4.3 | 197.2 | 223 | 120 | 107 | 27 | 69 | 94 | 12 | 0 | 0 | 2 | 12 | 5 | 6 | 4.95 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 90 | 0 | 6 | 6 | 2.94 | .276 | 1.14 | 7.4 | 2.8 | 9.9 | 98.0 | 81 | 32 | 32 | 10 | 31 | 108 | 0 | 9 | 1 | 0 | 0 | 0 | 2 | 3.07 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 52 | 0 | 2 | 2 | 3.73 | .291 | 1.23 | 6.4 | 4.8 | 8.0 | 62.2 | 44 | 26 | 26 | 9 | 33 | 55 | 0 | 3 | 3 | 0 | 0 | 0 | 3 | 4.71 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 33 | 0 | 0 | 2 | 4.79 | .348 | 1.49 | 7.5 | 6.2 | 8.7 | 35.2 | 29 | 22 | 19 | 2 | 24 | 34 | 0 | 3 | 0 | 0 | 0 | 4 | 2 | 4.20 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 21 | 0 | 4 | 0 | 1.05 | .238 | 0.86 | 4.3 | 3.6 | 11.5 | 25.2 | 12 | 3 | 3 | 1 | 10 | 32 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.40 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 22 | 0 | 1 | 2 | 2.73 | .310 | 1.25 | 7.8 | 3.7 | 5.3 | 29.2 | 25 | 9 | 9 | 3 | 12 | 17 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.72 |