| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 9 | 9 | 2 | 3 | 4.97 | .339 | 1.54 | 10.1 | 4.0 | 8.6 | 50.2 | 56 | 28 | 28 | 6 | 22 | 48 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 3.96 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 9 | 9 | 2 | 4 | 6.90 | .357 | 1.67 | 10.8 | 4.3 | 8.0 | 44.1 | 53 | 36 | 34 | 9 | 21 | 39 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.32 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 9 | 9 | 3 | 4 | 4.27 | .344 | 1.51 | 10.2 | 3.5 | 7.6 | 46.1 | 52 | 27 | 22 | 5 | 18 | 39 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 4.09 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 9 | 9 | 2 | 4 | 5.68 | .370 | 1.71 | 9.4 | 6.1 | 8.2 | 44.1 | 46 | 30 | 28 | 8 | 30 | 40 | 0 | 0 | 0 | 0 | 3 | 2 | 3 | 5.73 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 8 | 8 | 3 | 2 | 4.43 | .316 | 1.37 | 8.2 | 4.3 | 9.8 | 44.2 | 40 | 23 | 22 | 8 | 21 | 48 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.68 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 22 | 0 | 2 | 1 | 2.56 | .252 | 1.01 | 6.7 | 2.6 | 9.6 | 31.2 | 23 | 11 | 9 | 3 | 9 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 25 | 0 | 1 | 1 | 4.81 | .365 | 1.73 | 10.5 | 5.3 | 7.1 | 24.1 | 28 | 14 | 13 | 3 | 14 | 19 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 4.79 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 22 | 0 | 1 | 2 | 2.53 | .281 | 1.17 | 5.6 | 5.1 | 10.7 | 21.1 | 13 | 6 | 6 | 0 | 12 | 25 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.33 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 1 | 0 | 1 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 0.0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |