| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 9 | 9 | 5 | 2 | 2.95 | .244 | 0.97 | 6.9 | 1.8 | 11.2 | 61.0 | 47 | 20 | 20 | 5 | 12 | 76 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 2.16 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 8 | 8 | 6 | 2 | 2.85 | .302 | 1.30 | 8.4 | 3.3 | 5.6 | 60.0 | 56 | 22 | 19 | 6 | 22 | 37 | 2 | 0 | 0 | 0 | 7 | 0 | 2 | 4.17 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 7 | 7 | 4 | 2 | 2.37 | .256 | 1.03 | 7.0 | 2.4 | 5.0 | 49.1 | 38 | 14 | 13 | 5 | 13 | 27 | 1 | 0 | 0 | 0 | 6 | 0 | 1 | 4.02 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 22 | 0 | 2 | 1 | 1.29 | .203 | 0.71 | 2.6 | 3.9 | 7.3 | 21.0 | 6 | 3 | 3 | 2 | 9 | 17 | 0 | 18 | 1 | 0 | 0 | 1 | 0 | 4.05 |
| SU | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 21 | 0 | 0 | 0 | 0.87 | .253 | 0.97 | 5.9 | 3.2 | 6.8 | 20.2 | 13 | 3 | 2 | 0 | 7 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.70 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 13 | 0 | 0 | 0 | 2.70 | .318 | 1.40 | 10.8 | 1.8 | 8.1 | 10.0 | 12 | 3 | 3 | 1 | 2 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.10 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 15 | 0 | 1 | 0 | 0.93 | .171 | 0.62 | 3.0 | 3.0 | 9.0 | 9.2 | 3 | 1 | 1 | 1 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.44 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 12 | 0 | 1 | 0 | 1.93 | .222 | 0.75 | 4.0 | 3.0 | 11.0 | 9.1 | 4 | 2 | 2 | 2 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.78 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 3 | 0 | 0 | 0 | 0.00 | .154 | 0.55 | 5.1 | 0.0 | 7.7 | 7.1 | 4 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.29 |