| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 92 | 33 | 33 | 14 | 11 | 4.37 | .330 | 1.46 | 9.4 | 3.8 | 7.5 | 199.2 | 207 | 102 | 97 | 25 | 85 | 165 | 0 | 0 | 0 | 0 | 17 | 3 | 5 | 4.30 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 32 | 32 | 13 | 9 | 3.79 | .298 | 1.26 | 9.0 | 2.4 | 4.2 | 220.2 | 219 | 100 | 93 | 22 | 58 | 103 | 3 | 0 | 0 | 2 | 20 | 4 | 6 | 4.21 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 32 | 32 | 10 | 8 | 4.00 | .298 | 1.26 | 7.5 | 3.9 | 8.8 | 189.0 | 157 | 91 | 84 | 26 | 81 | 185 | 1 | 0 | 0 | 1 | 20 | 3 | 5 | 4.16 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 32 | 32 | 11 | 13 | 5.35 | .341 | 1.55 | 8.4 | 5.6 | 4.2 | 175.0 | 163 | 105 | 104 | 16 | 108 | 81 | 2 | 0 | 0 | 1 | 15 | 1 | 2 | 5.13 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 70 | 0 | 5 | 5 | 5.15 | .313 | 1.32 | 8.5 | 3.5 | 10.5 | 85.2 | 80 | 49 | 49 | 13 | 33 | 99 | 0 | 2 | 2 | 0 | 0 | 4 | 2 | 3.96 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 61 | 0 | 5 | 3 | 3.79 | .307 | 1.30 | 6.1 | 5.7 | 9.9 | 71.1 | 48 | 34 | 30 | 3 | 45 | 78 | 0 | 3 | 4 | 0 | 0 | 2 | 4 | 3.34 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 63 | 0 | 2 | 1 | 3.39 | .304 | 1.29 | 7.9 | 3.6 | 9.1 | 77.0 | 68 | 29 | 29 | 7 | 31 | 78 | 0 | 0 | 4 | 0 | 0 | 2 | 1 | 3.44 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 26 | 0 | 3 | 6 | 3.25 | .307 | 1.27 | 7.4 | 4.2 | 8.5 | 52.2 | 43 | 19 | 19 | 9 | 24 | 49 | 0 | 3 | 2 | 0 | 0 | 3 | 1 | 4.92 |