| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 31 | 31 | 16 | 7 | 3.73 | .271 | 1.08 | 7.7 | 2.0 | 9.0 | 234.0 | 200 | 100 | 97 | 23 | 53 | 233 | 7 | 0 | 0 | 2 | 18 | 8 | 0 | 3.07 |
| SP | Kluber, C.Kluber, Corey † # >> | 31 | 2017 | R | 90 | 29 | 29 | 12 | 14 | 4.97 | .318 | 1.39 | 9.8 | 2.8 | 8.8 | 211.2 | 229 | 121 | 117 | 27 | 66 | 206 | 9 | 0 | 0 | 1 | 13 | 1 | 1 | 3.66 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 30 | 30 | 6 | 12 | 5.30 | .331 | 1.48 | 9.7 | 3.7 | 7.2 | 197.0 | 212 | 124 | 116 | 28 | 80 | 158 | 3 | 0 | 0 | 0 | 11 | 1 | 8 | 4.48 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 29 | 29 | 8 | 13 | 5.30 | .339 | 1.53 | 10.1 | 3.7 | 4.6 | 185.0 | 207 | 118 | 109 | 22 | 76 | 95 | 2 | 0 | 0 | 0 | 10 | 2 | 3 | 4.78 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 29 | 29 | 13 | 10 | 5.07 | .341 | 1.50 | 10.4 | 3.2 | 4.8 | 175.2 | 202 | 108 | 99 | 13 | 62 | 94 | 0 | 0 | 0 | 0 | 15 | 9 | 2 | 4.11 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 78 | 0 | 6 | 5 | 2.93 | .269 | 1.09 | 7.0 | 2.8 | 9.9 | 101.1 | 79 | 35 | 33 | 10 | 31 | 111 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 3.07 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 68 | 0 | 2 | 4 | 2.67 | .269 | 1.09 | 5.9 | 4.0 | 7.0 | 84.1 | 55 | 25 | 25 | 6 | 37 | 65 | 0 | 8 | 3 | 0 | 0 | 1 | 2 | 3.74 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 45 | 0 | 3 | 4 | 4.59 | .297 | 1.24 | 7.2 | 4.0 | 9.7 | 49.0 | 39 | 25 | 25 | 7 | 22 | 53 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 4.10 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 36 | 0 | 4 | 4 | 2.66 | .267 | 1.09 | 7.8 | 2.0 | 6.8 | 44.0 | 38 | 13 | 13 | 3 | 10 | 33 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 18 | 0 | 0 | 1 | 1.71 | .259 | 1.05 | 6.0 | 3.4 | 12.0 | 21.0 | 14 | 4 | 4 | 2 | 8 | 28 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2.71 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 21 | 0 | 2 | 2 | 4.15 | .337 | 1.52 | 10.7 | 3.4 | 8.1 | 21.2 | 25 | 10 | 10 | 3 | 8 | 19 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.19 |