| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 15 | 15 | 8 | 4 | 3.88 | .301 | 1.29 | 8.8 | 2.9 | 7.8 | 106.2 | 104 | 53 | 46 | 7 | 34 | 92 | 3 | 0 | 0 | 3 | 7 | 0 | 2 | 3.08 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 15 | 15 | 8 | 6 | 4.81 | .292 | 1.22 | 8.6 | 2.4 | 4.8 | 101.0 | 96 | 57 | 54 | 9 | 27 | 54 | 4 | 0 | 0 | 0 | 6 | 2 | 3 | 3.95 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 14 | 14 | 5 | 7 | 5.36 | .329 | 1.43 | 9.6 | 3.3 | 4.2 | 94.0 | 100 | 59 | 56 | 13 | 34 | 44 | 4 | 0 | 0 | 1 | 5 | 4 | 1 | 5.07 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 14 | 13 | 4 | 6 | 6.62 | .370 | 1.75 | 9.9 | 5.9 | 8.0 | 69.1 | 76 | 53 | 51 | 10 | 45 | 61 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 5.12 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 36 | 0 | 1 | 0 | 3.89 | .320 | 1.41 | 7.4 | 5.6 | 9.3 | 34.2 | 28 | 15 | 15 | 5 | 21 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.71 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 33 | 0 | 0 | 2 | 3.81 | .366 | 1.69 | 9.3 | 6.1 | 6.8 | 28.1 | 29 | 15 | 12 | 2 | 19 | 21 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 4.57 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 21 | 0 | 1 | 1 | 4.09 | .298 | 1.27 | 6.5 | 4.9 | 11.5 | 22.0 | 16 | 12 | 10 | 3 | 12 | 28 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.86 |