| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 31 | 31 | 18 | 7 | 2.79 | .274 | 1.12 | 8.2 | 1.9 | 7.6 | 238.1 | 216 | 77 | 74 | 20 | 51 | 202 | 5 | 0 | 0 | 1 | 23 | 3 | 8 | 3.08 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 30 | 30 | 17 | 8 | 3.21 | .278 | 1.14 | 7.0 | 3.3 | 5.1 | 199.1 | 154 | 81 | 71 | 20 | 74 | 113 | 4 | 0 | 0 | 2 | 20 | 2 | 2 | 4.32 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 29 | 29 | 9 | 11 | 4.10 | .308 | 1.32 | 8.7 | 3.3 | 7.0 | 193.1 | 186 | 94 | 88 | 28 | 70 | 150 | 3 | 0 | 0 | 0 | 17 | 2 | 11 | 4.45 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 79 | 0 | 2 | 0 | 2.36 | .262 | 1.02 | 5.5 | 3.8 | 9.1 | 72.1 | 44 | 21 | 19 | 9 | 30 | 73 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.97 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 56 | 0 | 2 | 3 | 3.10 | .290 | 1.20 | 7.4 | 3.5 | 8.0 | 52.1 | 43 | 21 | 18 | 7 | 20 | 46 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.19 |
| RP | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 78 | 80 | 0 | 6 | 1 | 1.85 | .272 | 1.11 | 6.3 | 3.7 | 7.4 | 73.0 | 51 | 17 | 15 | 5 | 30 | 60 | 0 | 4 | 0 | 0 | 0 | 1 | 5 | 3.52 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 1 | 0 | 0 | 1 | 3.86 | .222 | 0.86 | 4.5 | 4.5 | 0.0 | 2.1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 64 | 0 | 4 | 6 | 3.59 | .293 | 1.23 | 7.0 | 4.2 | 8.1 | 67.2 | 52 | 29 | 27 | 13 | 31 | 60 | 0 | 31 | 4 | 0 | 0 | 1 | 0 | 5.16 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 13 | 0 | 0 | 0 | 4.09 | .233 | 0.91 | 5.7 | 2.5 | 9.8 | 11.0 | 7 | 5 | 5 | 2 | 3 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.00 |