| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 31 | 31 | 9 | 10 | 2.90 | .272 | 1.11 | 7.5 | 2.5 | 9.8 | 195.1 | 163 | 78 | 63 | 24 | 54 | 212 | 0 | 0 | 0 | 0 | 21 | 2 | 0 | 3.29 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 30 | 30 | 7 | 14 | 4.40 | .328 | 1.44 | 9.8 | 3.2 | 7.6 | 176.0 | 192 | 102 | 86 | 17 | 62 | 148 | 0 | 0 | 0 | 0 | 15 | 4 | 2 | 3.70 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 29 | 29 | 9 | 11 | 4.67 | .300 | 1.26 | 9.3 | 2.1 | 4.6 | 165.2 | 170 | 104 | 86 | 19 | 39 | 84 | 3 | 0 | 0 | 1 | 14 | 4 | 1 | 4.26 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 30 | 29 | 9 | 14 | 5.60 | .330 | 1.47 | 10.2 | 3.0 | 4.1 | 167.0 | 190 | 117 | 104 | 30 | 55 | 76 | 3 | 0 | 0 | 0 | 11 | 2 | 1 | 5.45 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 78 | 0 | 4 | 4 | 3.29 | .317 | 1.37 | 6.6 | 5.8 | 10.4 | 87.2 | 64 | 35 | 32 | 7 | 56 | 101 | 0 | 3 | 5 | 0 | 0 | 2 | 2 | 3.72 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 84 | 0 | 8 | 11 | 3.53 | .273 | 1.11 | 8.3 | 1.7 | 8.5 | 99.1 | 91 | 48 | 39 | 10 | 19 | 93 | 0 | 26 | 7 | 0 | 0 | 2 | 0 | 3.07 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 84 | 0 | 4 | 1 | 3.75 | .320 | 1.36 | 8.0 | 4.4 | 5.8 | 105.2 | 93 | 52 | 44 | 10 | 51 | 68 | 0 | 2 | 2 | 0 | 0 | 5 | 0 | 4.54 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 69 | 0 | 3 | 6 | 4.82 | .390 | 1.85 | 9.6 | 7.2 | 9.9 | 80.1 | 85 | 60 | 43 | 12 | 64 | 88 | 0 | 0 | 5 | 0 | 0 | 5 | 2 | 5.34 |