| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 30 | 30 | 12 | 16 | 4.63 | .297 | 1.26 | 9.3 | 2.1 | 5.2 | 223.2 | 230 | 122 | 115 | 29 | 52 | 130 | 7 | 0 | 0 | 1 | 13 | 2 | 2 | 4.25 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 29 | 29 | 10 | 12 | 5.49 | .321 | 1.40 | 9.1 | 3.5 | 9.0 | 183.2 | 185 | 120 | 112 | 42 | 72 | 184 | 1 | 0 | 0 | 1 | 13 | 3 | 3 | 5.20 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 29 | 29 | 18 | 7 | 4.26 | .301 | 1.26 | 9.0 | 2.4 | 4.3 | 228.0 | 228 | 112 | 108 | 31 | 60 | 108 | 10 | 0 | 0 | 1 | 14 | 7 | 3 | 4.70 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 26 | 26 | 10 | 12 | 4.61 | .324 | 1.42 | 9.7 | 3.1 | 4.5 | 197.0 | 213 | 112 | 101 | 22 | 67 | 99 | 7 | 0 | 0 | 0 | 13 | 3 | 8 | 4.51 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 75 | 0 | 4 | 6 | 3.36 | .290 | 1.23 | 8.4 | 2.7 | 8.4 | 93.2 | 87 | 39 | 35 | 8 | 28 | 87 | 0 | 13 | 7 | 0 | 0 | 0 | 0 | 3.15 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 57 | 0 | 0 | 5 | 3.41 | .298 | 1.26 | 8.1 | 3.3 | 7.7 | 71.1 | 64 | 28 | 27 | 1 | 26 | 61 | 0 | 4 | 2 | 0 | 0 | 1 | 4 | 2.61 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 46 | 0 | 3 | 2 | 3.00 | .282 | 1.18 | 7.2 | 3.4 | 9.7 | 51.0 | 41 | 17 | 17 | 3 | 19 | 55 | 0 | 9 | 1 | 0 | 0 | 0 | 2 | 2.73 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 28 | 0 | 4 | 4 | 4.73 | .365 | 1.73 | 13.5 | 2.4 | 11.8 | 26.2 | 39 | 14 | 14 | 4 | 7 | 34 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.19 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 20 | 0 | 1 | 0 | 4.43 | .323 | 1.41 | 7.7 | 5.1 | 4.9 | 42.2 | 36 | 24 | 21 | 7 | 24 | 23 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.86 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 2 | 2 | 0 | 1 | 6.14 | .389 | 1.84 | 14.1 | 3.2 | 3.9 | 14.2 | 22 | 10 | 10 | 1 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.36 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 3 | 0 | 0 | 0 | 3.18 | .346 | 1.59 | 9.0 | 7.2 | 3.6 | 5.2 | 5 | 3 | 2 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.60 |