| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 8 | 4 | 3.18 | .261 | 1.03 | 6.6 | 2.6 | 9.1 | 102.0 | 75 | 36 | 36 | 11 | 30 | 103 | 0 | 0 | 0 | 0 | 11 | 3 | 0 | 3.35 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 15 | 15 | 2 | 9 | 6.25 | .346 | 1.54 | 10.7 | 3.2 | 7.2 | 86.1 | 102 | 61 | 60 | 14 | 31 | 69 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 4.73 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 15 | 15 | 4 | 7 | 5.69 | .329 | 1.45 | 8.7 | 4.4 | 9.3 | 93.1 | 90 | 64 | 59 | 13 | 45 | 96 | 1 | 0 | 0 | 1 | 6 | 2 | 2 | 4.27 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 14 | 14 | 2 | 6 | 5.77 | .331 | 1.46 | 10.2 | 3.0 | 4.7 | 73.1 | 83 | 48 | 47 | 8 | 24 | 38 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.45 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 35 | 0 | 2 | 2 | 2.19 | .279 | 1.14 | 8.3 | 1.9 | 10.7 | 37.0 | 34 | 9 | 9 | 2 | 8 | 44 | 0 | 17 | 2 | 0 | 0 | 1 | 0 | 2.05 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 32 | 0 | 1 | 4 | 6.62 | .373 | 1.78 | 10.0 | 6.2 | 7.2 | 35.1 | 39 | 27 | 26 | 5 | 24 | 28 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 5.31 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 41 | 0 | 1 | 2 | 4.50 | .333 | 1.50 | 8.4 | 5.1 | 9.2 | 44.0 | 41 | 22 | 22 | 9 | 25 | 45 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.32 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 36 | 0 | 1 | 2 | 4.46 | .313 | 1.34 | 9.0 | 3.2 | 7.0 | 40.1 | 40 | 21 | 20 | 5 | 14 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.20 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 31 | 0 | 3 | 1 | 2.54 | .245 | 0.97 | 4.8 | 3.9 | 10.4 | 39.0 | 21 | 11 | 11 | 3 | 17 | 45 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 8 | 0 | 0 | 1 | 5.11 | .302 | 1.30 | 11.3 | 0.8 | 5.3 | 12.1 | 15 | 7 | 7 | 3 | 1 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.33 |