| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 27 | 27 | 10 | 9 | 3.33 | .279 | 1.14 | 7.7 | 2.6 | 7.8 | 181.1 | 155 | 68 | 67 | 22 | 52 | 157 | 1 | 0 | 0 | 1 | 19 | 4 | 0 | 3.77 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 64 | 24 | 24 | 12 | 5 | 3.42 | .287 | 1.19 | 8.2 | 2.5 | 8.3 | 157.2 | 143 | 61 | 60 | 15 | 44 | 145 | 0 | 0 | 0 | 0 | 15 | 3 | 4 | 3.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 67 | 0 | 6 | 3 | 3.53 | .245 | 0.97 | 6.3 | 2.5 | 8.9 | 91.2 | 64 | 38 | 36 | 12 | 25 | 90 | 0 | 11 | 1 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 52 | 0 | 5 | 4 | 3.38 | .291 | 1.23 | 7.6 | 3.5 | 8.9 | 66.2 | 56 | 26 | 25 | 8 | 26 | 65 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.79 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 47 | 0 | 4 | 5 | 3.99 | .279 | 1.14 | 5.7 | 4.7 | 10.2 | 58.2 | 37 | 26 | 26 | 8 | 30 | 66 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.12 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 27 | 0 | 2 | 0 | 2.48 | .259 | 1.05 | 8.5 | 1.0 | 6.0 | 36.1 | 34 | 10 | 10 | 3 | 4 | 24 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.08 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 19 | 0 | 2 | 1 | 2.38 | .244 | 0.97 | 5.3 | 3.7 | 5.7 | 22.2 | 13 | 6 | 6 | 3 | 9 | 14 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.73 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 14 | 0 | 0 | 3 | 2.35 | .193 | 0.72 | 4.2 | 2.4 | 8.4 | 15.1 | 7 | 4 | 4 | 2 | 4 | 14 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 18 | 0 | 1 | 1 | 6.19 | .324 | 1.44 | 9.0 | 3.9 | 9.0 | 16.0 | 16 | 11 | 11 | 2 | 7 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.94 |