| SP | Zito, B.Zito, Barry † # >> | 22 | 2000 | L | 97 | 33 | 33 | 14 | 9 | 3.56 | .298 | 1.27 | 7.9 | 3.5 | 6.6 | 222.2 | 195 | 89 | 88 | 22 | 87 | 162 | 6 | 0 | 0 | 2 | 21 | 1 | 6 | 4.02 |
| SP | Clemens, R.Clemens, Roger >> | 38 | 2000 | R | 83 | 33 | 33 | 12 | 8 | 5.46 | .345 | 1.56 | 9.5 | 4.5 | 6.7 | 178.0 | 188 | 114 | 108 | 28 | 89 | 132 | 0 | 0 | 0 | 0 | 16 | 4 | 3 | 5.13 |
| SP | Pavano, C.Pavano, Carl >> | 24 | 2000 | R | 78 | 32 | 32 | 14 | 8 | 3.83 | .319 | 1.38 | 8.3 | 4.1 | 6.0 | 207.0 | 192 | 91 | 88 | 23 | 94 | 138 | 0 | 0 | 0 | 0 | 22 | 5 | 5 | 4.55 |
| SP | Colon, B.Colon, Bartolo >> | 27 | 2000 | R | 69 | 31 | 31 | 7 | 11 | 5.30 | .351 | 1.60 | 9.4 | 4.9 | 8.3 | 168.0 | 176 | 100 | 99 | 20 | 92 | 154 | 0 | 0 | 0 | 0 | 14 | 4 | 1 | 4.43 |
| CL | Benitez, A.Benitez, Armando >> | 28 | 2000 | R | 99 | 67 | 0 | 1 | 4 | 2.44 | .268 | 1.06 | 5.9 | 3.7 | 7.9 | 66.1 | 43 | 18 | 18 | 2 | 27 | 58 | 0 | 44 | 6 | 0 | 0 | 3 | 0 | 3.00 |
| RP | Sullivan, S.Sullivan, Scott # >> | 29 | 2000 | R | 84 | 89 | 0 | 12 | 4 | 4.24 | .290 | 1.19 | 7.8 | 3.0 | 7.1 | 127.1 | 110 | 61 | 60 | 10 | 42 | 100 | 0 | 3 | 3 | 0 | 0 | 4 | 10 | 3.54 |
| RP | Wendell, T.Wendell, Turk >> | 33 | 2000 | R | 86 | 68 | 0 | 6 | 4 | 3.58 | .332 | 1.43 | 7.8 | 5.1 | 6.3 | 83.0 | 72 | 35 | 33 | 6 | 47 | 58 | 0 | 1 | 3 | 0 | 0 | 5 | 0 | 4.42 |
| RP | Speier, J.Speier, Justin >> | 27 | 2000 | R | 78 | 44 | 0 | 6 | 5 | 3.54 | .307 | 1.29 | 8.7 | 3.1 | 8.8 | 53.1 | 51 | 27 | 21 | 4 | 18 | 52 | 0 | 1 | 2 | 0 | 0 | 2 | 5 | 3.15 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 28 | 2000 | R | 71 | 28 | 0 | 1 | 2 | 7.01 | .389 | 1.87 | 12.6 | 4.7 | 8.6 | 25.2 | 35 | 21 | 20 | 6 | 13 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.88 |
| RP | Leskanic, C.Leskanic, Curt >> | 32 | 2000 | R | 55 | 25 | 0 | 0 | 0 | 4.15 | .326 | 1.42 | 8.1 | 4.8 | 7.8 | 30.1 | 27 | 14 | 14 | 3 | 16 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.27 |