| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 10 | 10 | 2 | 3 | 3.82 | .277 | 1.12 | 7.9 | 2.2 | 10.9 | 66.0 | 58 | 28 | 28 | 9 | 16 | 80 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 3.17 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 10 | 10 | 0 | 3 | 7.01 | .367 | 1.67 | 10.3 | 5.0 | 9.0 | 43.2 | 49 | 34 | 34 | 6 | 24 | 43 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 4.70 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 73 | 11 | 9 | 3 | 4 | 4.53 | .274 | 1.11 | 8.3 | 1.8 | 9.8 | 55.2 | 51 | 28 | 28 | 12 | 11 | 60 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.31 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 61 | 9 | 9 | 0 | 2 | 4.62 | .339 | 1.49 | 10.4 | 3.0 | 7.2 | 39.0 | 45 | 20 | 20 | 5 | 13 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 4.23 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 90 | 35 | 0 | 2 | 1 | 3.86 | .323 | 1.40 | 8.0 | 4.6 | 7.2 | 35.0 | 31 | 15 | 15 | 2 | 18 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.77 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 32 | 0 | 1 | 3 | 3.89 | .268 | 1.10 | 6.4 | 3.7 | 5.3 | 34.2 | 24 | 15 | 15 | 5 | 14 | 20 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 4.97 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 70 | 27 | 0 | 2 | 2 | 2.43 | .265 | 1.05 | 6.6 | 2.9 | 8.8 | 37.0 | 27 | 10 | 10 | 2 | 12 | 36 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 2.81 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 30 | 0 | 3 | 4 | 5.04 | .350 | 1.58 | 10.8 | 3.6 | 8.7 | 30.1 | 36 | 21 | 17 | 6 | 12 | 29 | 0 | 0 | 7 | 0 | 0 | 1 | 2 | 4.97 |